Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo
Duck tembusu virus (DTMUV) is newly emerged in poultry and causes great losses to the breeding industry in China and neighboring countries. Effective antiviral strategies are still being studied. Autophagy is a cellular degradative pathway, and our lab's previous data show that autophagy promot...
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00155/full |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zhiqiang Hu Zhiqiang Hu Zhiqiang Hu Yuhong Pan Yuhong Pan Yuhong Pan Anchun Cheng Anchun Cheng Anchun Cheng Xingcui Zhang Xingcui Zhang Xingcui Zhang Mingshu Wang Mingshu Wang Mingshu Wang Shun Chen Shun Chen Shun Chen Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Xinxin Zhao Xinxin Zhao Xinxin Zhao Juan Huang Juan Huang Juan Huang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Sai Mao Sai Mao Sai Mao Xumin Ou Xumin Ou Xumin Ou Yanling Yu Yanling Yu Yanling Yu Ling Zhang Ling Zhang Ling Zhang Yunya Liu Yunya Liu Yunya Liu Bin Tian Bin Tian Bin Tian Leichang Pan Leichang Pan Leichang Pan Mujeeb Ur Rehman Mujeeb Ur Rehman Mujeeb Ur Rehman Zhongqiong Yin Renyong Jia Renyong Jia Renyong Jia |
| spellingShingle |
Zhiqiang Hu Zhiqiang Hu Zhiqiang Hu Yuhong Pan Yuhong Pan Yuhong Pan Anchun Cheng Anchun Cheng Anchun Cheng Xingcui Zhang Xingcui Zhang Xingcui Zhang Mingshu Wang Mingshu Wang Mingshu Wang Shun Chen Shun Chen Shun Chen Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Xinxin Zhao Xinxin Zhao Xinxin Zhao Juan Huang Juan Huang Juan Huang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Sai Mao Sai Mao Sai Mao Xumin Ou Xumin Ou Xumin Ou Yanling Yu Yanling Yu Yanling Yu Ling Zhang Ling Zhang Ling Zhang Yunya Liu Yunya Liu Yunya Liu Bin Tian Bin Tian Bin Tian Leichang Pan Leichang Pan Leichang Pan Mujeeb Ur Rehman Mujeeb Ur Rehman Mujeeb Ur Rehman Zhongqiong Yin Renyong Jia Renyong Jia Renyong Jia Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo Frontiers in Cellular and Infection Microbiology DTMUV autophagy spleen brain tissue damage replication |
| author_facet |
Zhiqiang Hu Zhiqiang Hu Zhiqiang Hu Yuhong Pan Yuhong Pan Yuhong Pan Anchun Cheng Anchun Cheng Anchun Cheng Xingcui Zhang Xingcui Zhang Xingcui Zhang Mingshu Wang Mingshu Wang Mingshu Wang Shun Chen Shun Chen Shun Chen Dekang Zhu Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Qiao Yang Qiao Yang Qiao Yang Ying Wu Ying Wu Ying Wu Xinxin Zhao Xinxin Zhao Xinxin Zhao Juan Huang Juan Huang Juan Huang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Sai Mao Sai Mao Sai Mao Xumin Ou Xumin Ou Xumin Ou Yanling Yu Yanling Yu Yanling Yu Ling Zhang Ling Zhang Ling Zhang Yunya Liu Yunya Liu Yunya Liu Bin Tian Bin Tian Bin Tian Leichang Pan Leichang Pan Leichang Pan Mujeeb Ur Rehman Mujeeb Ur Rehman Mujeeb Ur Rehman Zhongqiong Yin Renyong Jia Renyong Jia Renyong Jia |
| author_sort |
Zhiqiang Hu |
| title |
Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo |
| title_short |
Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo |
| title_full |
Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo |
| title_fullStr |
Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo |
| title_full_unstemmed |
Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo |
| title_sort |
autophagy is a potential therapeutic target against duck tembusu virus infection in vivo |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cellular and Infection Microbiology |
| issn |
2235-2988 |
| publishDate |
2020-04-01 |
| description |
Duck tembusu virus (DTMUV) is newly emerged in poultry and causes great losses to the breeding industry in China and neighboring countries. Effective antiviral strategies are still being studied. Autophagy is a cellular degradative pathway, and our lab's previous data show that autophagy promotes DTMUV replication in vitro. To study the role of autophagy further in vivo, we utilized ducks as the animal model to investigate the autophagy responses in DTMUV-targeted tissues. And also, we utilized autophagy regulators, including Rapamycin (Rapa) as the autophagy enhancer, 3-Methyladenine (3-MA) and Chloroquine (CQ) as the autophagy inhibitors, to adjust the host autophagic levels and then study the effects of autophagy on tissue damages and virus replication. As a result, we first found DTMUV infection trigged autophagy and autophagy regulator treatments regulated autophagy levels successfully in duck spleens and brains. Next, we found that autophagy inhibitors inhibited DTMUV replication and alleviated DTMUV-induced pathological symptoms, whereas the autophagy inducer treatment led to the opposite effects. And we also found that autophagic regulation was correlated with the expression of innate immune genes, including pattern recognition receptors, type I interferons, and cytokines, and caused different effects in different tissues. In summary, we demonstrated that autophagy facilitated DTMUV replication, aggravated the developments of pathological symptoms and possibly counteracts the host's innate immunity response in vivo. |
| topic |
DTMUV autophagy spleen brain tissue damage replication |
| url |
https://www.frontiersin.org/article/10.3389/fcimb.2020.00155/full |
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doaj-715ca803ba6748feb43ab81a970384f12020-11-25T02:32:19ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-04-011010.3389/fcimb.2020.00155531903Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivoZhiqiang Hu0Zhiqiang Hu1Zhiqiang Hu2Yuhong Pan3Yuhong Pan4Yuhong Pan5Anchun Cheng6Anchun Cheng7Anchun Cheng8Xingcui Zhang9Xingcui Zhang10Xingcui Zhang11Mingshu Wang12Mingshu Wang13Mingshu Wang14Shun Chen15Shun Chen16Shun Chen17Dekang Zhu18Dekang Zhu19Dekang Zhu20Mafeng Liu21Mafeng Liu22Mafeng Liu23Qiao Yang24Qiao Yang25Qiao Yang26Ying Wu27Ying Wu28Ying Wu29Xinxin Zhao30Xinxin Zhao31Xinxin Zhao32Juan Huang33Juan Huang34Juan Huang35Shaqiu Zhang36Shaqiu Zhang37Shaqiu Zhang38Sai Mao39Sai Mao40Sai Mao41Xumin Ou42Xumin Ou43Xumin Ou44Yanling Yu45Yanling Yu46Yanling Yu47Ling Zhang48Ling Zhang49Ling Zhang50Yunya Liu51Yunya Liu52Yunya Liu53Bin Tian54Bin Tian55Bin Tian56Leichang Pan57Leichang Pan58Leichang Pan59Mujeeb Ur Rehman60Mujeeb Ur Rehman61Mujeeb Ur Rehman62Zhongqiong Yin63Renyong Jia64Renyong Jia65Renyong Jia66Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, ChinaAvian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, ChinaDuck tembusu virus (DTMUV) is newly emerged in poultry and causes great losses to the breeding industry in China and neighboring countries. Effective antiviral strategies are still being studied. Autophagy is a cellular degradative pathway, and our lab's previous data show that autophagy promotes DTMUV replication in vitro. To study the role of autophagy further in vivo, we utilized ducks as the animal model to investigate the autophagy responses in DTMUV-targeted tissues. And also, we utilized autophagy regulators, including Rapamycin (Rapa) as the autophagy enhancer, 3-Methyladenine (3-MA) and Chloroquine (CQ) as the autophagy inhibitors, to adjust the host autophagic levels and then study the effects of autophagy on tissue damages and virus replication. As a result, we first found DTMUV infection trigged autophagy and autophagy regulator treatments regulated autophagy levels successfully in duck spleens and brains. Next, we found that autophagy inhibitors inhibited DTMUV replication and alleviated DTMUV-induced pathological symptoms, whereas the autophagy inducer treatment led to the opposite effects. And we also found that autophagic regulation was correlated with the expression of innate immune genes, including pattern recognition receptors, type I interferons, and cytokines, and caused different effects in different tissues. In summary, we demonstrated that autophagy facilitated DTMUV replication, aggravated the developments of pathological symptoms and possibly counteracts the host's innate immunity response in vivo.https://www.frontiersin.org/article/10.3389/fcimb.2020.00155/fullDTMUVautophagyspleenbraintissue damagereplication |