Anti-Angiogenic Properties of Ginsenoside Rg3
Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from <i>Panax ginseng</i>. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One...
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/4905 |
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doaj-71602661ddfe407aa03f9f9d3bdf50002020-11-25T03:32:45ZengMDPI AGMolecules1420-30492020-10-01254905490510.3390/molecules25214905Anti-Angiogenic Properties of Ginsenoside Rg3Maryam Nakhjavani0Eric Smith1Amanda R. Townsend2Timothy J. Price3Jennifer E. Hardingham4Molecular Oncology, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, SA 5011, AustraliaMolecular Oncology, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, SA 5011, AustraliaAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, AustraliaAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, AustraliaMolecular Oncology, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, SA 5011, AustraliaGinsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from <i>Panax ginseng</i>. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug.https://www.mdpi.com/1420-3049/25/21/4905ginsenoside Rg320(S)-ginsenoside Rg320(R)-ginsenoside Rg3angiogenesisepimer |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Maryam Nakhjavani Eric Smith Amanda R. Townsend Timothy J. Price Jennifer E. Hardingham |
| spellingShingle |
Maryam Nakhjavani Eric Smith Amanda R. Townsend Timothy J. Price Jennifer E. Hardingham Anti-Angiogenic Properties of Ginsenoside Rg3 Molecules ginsenoside Rg3 20(S)-ginsenoside Rg3 20(R)-ginsenoside Rg3 angiogenesis epimer |
| author_facet |
Maryam Nakhjavani Eric Smith Amanda R. Townsend Timothy J. Price Jennifer E. Hardingham |
| author_sort |
Maryam Nakhjavani |
| title |
Anti-Angiogenic Properties of Ginsenoside Rg3 |
| title_short |
Anti-Angiogenic Properties of Ginsenoside Rg3 |
| title_full |
Anti-Angiogenic Properties of Ginsenoside Rg3 |
| title_fullStr |
Anti-Angiogenic Properties of Ginsenoside Rg3 |
| title_full_unstemmed |
Anti-Angiogenic Properties of Ginsenoside Rg3 |
| title_sort |
anti-angiogenic properties of ginsenoside rg3 |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2020-10-01 |
| description |
Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from <i>Panax ginseng</i>. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug. |
| topic |
ginsenoside Rg3 20(S)-ginsenoside Rg3 20(R)-ginsenoside Rg3 angiogenesis epimer |
| url |
https://www.mdpi.com/1420-3049/25/21/4905 |
| work_keys_str_mv |
AT maryamnakhjavani antiangiogenicpropertiesofginsenosiderg3 AT ericsmith antiangiogenicpropertiesofginsenosiderg3 AT amandartownsend antiangiogenicpropertiesofginsenosiderg3 AT timothyjprice antiangiogenicpropertiesofginsenosiderg3 AT jenniferehardingham antiangiogenicpropertiesofginsenosiderg3 |
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1724566201025167360 |