Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
Many forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin infla...
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2019-08-01
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Online Access: | https://doi.org/10.1038/s41467-019-11858-7 |
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doaj-716b05e17f3c43fa880e9ce7ddca92ca2021-05-11T11:35:14ZengNature Publishing GroupNature Communications2041-17232019-08-0110111610.1038/s41467-019-11858-7Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell deathKatsuhiro Sasaki0Ai Himeno1Tomoko Nakagawa2Yoshiteru Sasaki3Hiroshi Kiyonari4Kazuhiro Iwai5Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityAnimal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science TechnologiesDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityMany forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin inflammation similar to cpdm mice with genetic deletion of Sharpin.https://doi.org/10.1038/s41467-019-11858-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katsuhiro Sasaki Ai Himeno Tomoko Nakagawa Yoshiteru Sasaki Hiroshi Kiyonari Kazuhiro Iwai |
spellingShingle |
Katsuhiro Sasaki Ai Himeno Tomoko Nakagawa Yoshiteru Sasaki Hiroshi Kiyonari Kazuhiro Iwai Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death Nature Communications |
author_facet |
Katsuhiro Sasaki Ai Himeno Tomoko Nakagawa Yoshiteru Sasaki Hiroshi Kiyonari Kazuhiro Iwai |
author_sort |
Katsuhiro Sasaki |
title |
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death |
title_short |
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death |
title_full |
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death |
title_fullStr |
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death |
title_full_unstemmed |
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death |
title_sort |
modulation of autoimmune pathogenesis by t cell-triggered inflammatory cell death |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-08-01 |
description |
Many forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin inflammation similar to cpdm mice with genetic deletion of Sharpin. |
url |
https://doi.org/10.1038/s41467-019-11858-7 |
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1721446307091972096 |