Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death

Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death

Many forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin infla...

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Main Authors: Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11858-7
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spelling doaj-716b05e17f3c43fa880e9ce7ddca92ca2021-05-11T11:35:14ZengNature Publishing GroupNature Communications2041-17232019-08-0110111610.1038/s41467-019-11858-7Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell deathKatsuhiro Sasaki0Ai Himeno1Tomoko Nakagawa2Yoshiteru Sasaki3Hiroshi Kiyonari4Kazuhiro Iwai5Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityAnimal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science TechnologiesDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto UniversityMany forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin inflammation similar to cpdm mice with genetic deletion of Sharpin.https://doi.org/10.1038/s41467-019-11858-7
collection DOAJ
language English
format Article
sources DOAJ
author Katsuhiro Sasaki
Ai Himeno
Tomoko Nakagawa
Yoshiteru Sasaki
Hiroshi Kiyonari
Kazuhiro Iwai
spellingShingle Katsuhiro Sasaki
Ai Himeno
Tomoko Nakagawa
Yoshiteru Sasaki
Hiroshi Kiyonari
Kazuhiro Iwai
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
Nature Communications
author_facet Katsuhiro Sasaki
Ai Himeno
Tomoko Nakagawa
Yoshiteru Sasaki
Hiroshi Kiyonari
Kazuhiro Iwai
author_sort Katsuhiro Sasaki
title Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_short Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_full Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_fullStr Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_full_unstemmed Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_sort modulation of autoimmune pathogenesis by t cell-triggered inflammatory cell death
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description Many forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin inflammation similar to cpdm mice with genetic deletion of Sharpin.
url https://doi.org/10.1038/s41467-019-11858-7
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AT yoshiterusasaki modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath
AT hiroshikiyonari modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath
AT kazuhiroiwai modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath
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