GDF15 Is a Novel Biomarker for Impaired Fasting Glucose
BackgroundGrowth differentiation factor-15 (GDF15) is a protein that belongs to the transforming growth factor β superfamily. An elevated serum level of GDF15 was found to be associated with type 2 diabetes mellitus (T2DM). T2DM is an inflammatory disease that progresses from normal glucose toleranc...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Korean Diabetes Association
2014-12-01
|
Series: | Diabetes & Metabolism Journal |
Subjects: | |
Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-472.pdf |
id |
doaj-71787e62c71c4884bc38e823368ed0d0 |
---|---|
record_format |
Article |
spelling |
doaj-71787e62c71c4884bc38e823368ed0d02020-11-24T21:31:52ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872014-12-0138647247910.4093/dmj.2014.38.6.47214657GDF15 Is a Novel Biomarker for Impaired Fasting GlucoseJun Hwa HongHyo Kyun ChungHye Yoon ParkKyong-Hye JoungJu Hee LeeJin Gyu JungKoon Soon KimHyun Jin KimBon Jeong KuMinho ShongBackgroundGrowth differentiation factor-15 (GDF15) is a protein that belongs to the transforming growth factor β superfamily. An elevated serum level of GDF15 was found to be associated with type 2 diabetes mellitus (T2DM). T2DM is an inflammatory disease that progresses from normal glucose tolerance (NGT) to impaired fasting glucose (IFG). Hence, we aimed to validate the relationship between GDF15 and IFG.MethodsThe participants were divided into the following three groups: NGT (n=137), IFG (n=29), and T2DM (n=75). The controls and T2DM outpatients visited the hospital for routine health check-ups. We used fasting blood glucose to detect IFG in nondiabetic patients. We checked the body mass index (BMI), C-reactive protein level, metabolic parameters, and fasting serum GDF15 level.ResultsAge, BMI, triglyceride, insulin, glucose, homeostatic model assessment-insulin resistance (HOMA-IR), and GDF15 levels were elevated in the IFG and T2DM groups compared to the NGT group. In the correlation analysis between metabolic parameters and GDF15, age and HOMA-IR had a significant positive correlation with GDF15 levels. GDF15 significantly discriminated between IFG and NGT, independent of age, BMI, and HOMA-IR. The serum levels of GDF15 were more elevated in men than in women. As a biomarker for IFG based on the receiver operating characteristic curve analysis, the cutoff value of GDF15 was 510 pg/mL in males and 400 pg/mL in females.ConclusionGDF15 had a positive correlation with IR independent of age and BMI, and the serum level of GDF15 was increased in the IFG and T2DM groups. GDF15 may be a novel biomarker for detecting IFG in nondiabetic patients.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-472.pdfBiological markersDiabetes mellitus, type 2Growth differentiation factor 15Prediabetic state |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Hwa Hong Hyo Kyun Chung Hye Yoon Park Kyong-Hye Joung Ju Hee Lee Jin Gyu Jung Koon Soon Kim Hyun Jin Kim Bon Jeong Ku Minho Shong |
spellingShingle |
Jun Hwa Hong Hyo Kyun Chung Hye Yoon Park Kyong-Hye Joung Ju Hee Lee Jin Gyu Jung Koon Soon Kim Hyun Jin Kim Bon Jeong Ku Minho Shong GDF15 Is a Novel Biomarker for Impaired Fasting Glucose Diabetes & Metabolism Journal Biological markers Diabetes mellitus, type 2 Growth differentiation factor 15 Prediabetic state |
author_facet |
Jun Hwa Hong Hyo Kyun Chung Hye Yoon Park Kyong-Hye Joung Ju Hee Lee Jin Gyu Jung Koon Soon Kim Hyun Jin Kim Bon Jeong Ku Minho Shong |
author_sort |
Jun Hwa Hong |
title |
GDF15 Is a Novel Biomarker for Impaired Fasting Glucose |
title_short |
GDF15 Is a Novel Biomarker for Impaired Fasting Glucose |
title_full |
GDF15 Is a Novel Biomarker for Impaired Fasting Glucose |
title_fullStr |
GDF15 Is a Novel Biomarker for Impaired Fasting Glucose |
title_full_unstemmed |
GDF15 Is a Novel Biomarker for Impaired Fasting Glucose |
title_sort |
gdf15 is a novel biomarker for impaired fasting glucose |
publisher |
Korean Diabetes Association |
series |
Diabetes & Metabolism Journal |
issn |
2233-6079 2233-6087 |
publishDate |
2014-12-01 |
description |
BackgroundGrowth differentiation factor-15 (GDF15) is a protein that belongs to the transforming growth factor β superfamily. An elevated serum level of GDF15 was found to be associated with type 2 diabetes mellitus (T2DM). T2DM is an inflammatory disease that progresses from normal glucose tolerance (NGT) to impaired fasting glucose (IFG). Hence, we aimed to validate the relationship between GDF15 and IFG.MethodsThe participants were divided into the following three groups: NGT (n=137), IFG (n=29), and T2DM (n=75). The controls and T2DM outpatients visited the hospital for routine health check-ups. We used fasting blood glucose to detect IFG in nondiabetic patients. We checked the body mass index (BMI), C-reactive protein level, metabolic parameters, and fasting serum GDF15 level.ResultsAge, BMI, triglyceride, insulin, glucose, homeostatic model assessment-insulin resistance (HOMA-IR), and GDF15 levels were elevated in the IFG and T2DM groups compared to the NGT group. In the correlation analysis between metabolic parameters and GDF15, age and HOMA-IR had a significant positive correlation with GDF15 levels. GDF15 significantly discriminated between IFG and NGT, independent of age, BMI, and HOMA-IR. The serum levels of GDF15 were more elevated in men than in women. As a biomarker for IFG based on the receiver operating characteristic curve analysis, the cutoff value of GDF15 was 510 pg/mL in males and 400 pg/mL in females.ConclusionGDF15 had a positive correlation with IR independent of age and BMI, and the serum level of GDF15 was increased in the IFG and T2DM groups. GDF15 may be a novel biomarker for detecting IFG in nondiabetic patients. |
topic |
Biological markers Diabetes mellitus, type 2 Growth differentiation factor 15 Prediabetic state |
url |
http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-472.pdf |
work_keys_str_mv |
AT junhwahong gdf15isanovelbiomarkerforimpairedfastingglucose AT hyokyunchung gdf15isanovelbiomarkerforimpairedfastingglucose AT hyeyoonpark gdf15isanovelbiomarkerforimpairedfastingglucose AT kyonghyejoung gdf15isanovelbiomarkerforimpairedfastingglucose AT juheelee gdf15isanovelbiomarkerforimpairedfastingglucose AT jingyujung gdf15isanovelbiomarkerforimpairedfastingglucose AT koonsoonkim gdf15isanovelbiomarkerforimpairedfastingglucose AT hyunjinkim gdf15isanovelbiomarkerforimpairedfastingglucose AT bonjeongku gdf15isanovelbiomarkerforimpairedfastingglucose AT minhoshong gdf15isanovelbiomarkerforimpairedfastingglucose |
_version_ |
1725959585107279872 |