MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition

MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition

Summary: The NuRD complex contains both chromatin remodeling and histone deacetylase activities. Mice lacking the MTA2 subunit of NuRD show developmental defects in pro-B, pre-B, immature B, and marginal zone B cells, and abnormal germinal center B cell differentiation during immune responses. Mta2...

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Bibliographic Details
Main Authors: Xiangdong Lu, Chi-Shuen Chu, Terry Fang, Violeta Rayon-Estrada, Fang Fang, Alina Patke, Ye Qian, Stephen H. Clarke, Ari M. Melnick, Yi Zhang, F. Nina Papavasiliou, Robert G. Roeder
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719307958

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