Regulation of lipid saturation without sensing membrane fluidity

Cells maintain membrane fluidity by regulating lipid saturation, but the molecular mechanisms of this homeoviscous adaptation remain poorly understood. Here authors reconstituted the core machinery for regulating lipid saturation in baker’s yeast to directly characterize its response to defined memb...

Full description

Bibliographic Details
Main Authors:	Stephanie Ballweg, Erdinc Sezgin, Milka Doktorova, Roberto Covino, John Reinhard, Dorith Wunnicke, Inga Hänelt, Ilya Levental, Gerhard Hummer, Robert Ernst
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14528-1

id	doaj-7183c9c33c7245fcb2bcf9a185481273
record_format	Article
spelling	doaj-7183c9c33c7245fcb2bcf9a1854812732021-05-11T08:25:54ZengNature Publishing GroupNature Communications2041-17232020-02-0111111310.1038/s41467-020-14528-1Regulation of lipid saturation without sensing membrane fluidityStephanie Ballweg0Erdinc Sezgin1Milka Doktorova2Roberto Covino3John Reinhard4Dorith Wunnicke5Inga Hänelt6Ilya Levental7Gerhard Hummer8Robert Ernst9Medical Biochemistry and Molecular Biology, Medical Faculty, Saarland UniversityMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Science CenterDepartment of Theoretical Biophysics, Max Planck Institute of BiophysicsMedical Biochemistry and Molecular Biology, Medical Faculty, Saarland UniversityInstitute of Biochemistry, Goethe University FrankfurtInstitute of Biochemistry, Goethe University FrankfurtDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Science CenterDepartment of Theoretical Biophysics, Max Planck Institute of BiophysicsMedical Biochemistry and Molecular Biology, Medical Faculty, Saarland UniversityCells maintain membrane fluidity by regulating lipid saturation, but the molecular mechanisms of this homeoviscous adaptation remain poorly understood. Here authors reconstituted the core machinery for regulating lipid saturation in baker’s yeast to directly characterize its response to defined membrane environments and uncover its mode-of-action.https://doi.org/10.1038/s41467-020-14528-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stephanie Ballweg Erdinc Sezgin Milka Doktorova Roberto Covino John Reinhard Dorith Wunnicke Inga Hänelt Ilya Levental Gerhard Hummer Robert Ernst
spellingShingle	Stephanie Ballweg Erdinc Sezgin Milka Doktorova Roberto Covino John Reinhard Dorith Wunnicke Inga Hänelt Ilya Levental Gerhard Hummer Robert Ernst Regulation of lipid saturation without sensing membrane fluidity Nature Communications
author_facet	Stephanie Ballweg Erdinc Sezgin Milka Doktorova Roberto Covino John Reinhard Dorith Wunnicke Inga Hänelt Ilya Levental Gerhard Hummer Robert Ernst
author_sort	Stephanie Ballweg
title	Regulation of lipid saturation without sensing membrane fluidity
title_short	Regulation of lipid saturation without sensing membrane fluidity
title_full	Regulation of lipid saturation without sensing membrane fluidity
title_fullStr	Regulation of lipid saturation without sensing membrane fluidity
title_full_unstemmed	Regulation of lipid saturation without sensing membrane fluidity
title_sort	regulation of lipid saturation without sensing membrane fluidity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-02-01
description	Cells maintain membrane fluidity by regulating lipid saturation, but the molecular mechanisms of this homeoviscous adaptation remain poorly understood. Here authors reconstituted the core machinery for regulating lipid saturation in baker’s yeast to directly characterize its response to defined membrane environments and uncover its mode-of-action.
url	https://doi.org/10.1038/s41467-020-14528-1
work_keys_str_mv	AT stephanieballweg regulationoflipidsaturationwithoutsensingmembranefluidity AT erdincsezgin regulationoflipidsaturationwithoutsensingmembranefluidity AT milkadoktorova regulationoflipidsaturationwithoutsensingmembranefluidity AT robertocovino regulationoflipidsaturationwithoutsensingmembranefluidity AT johnreinhard regulationoflipidsaturationwithoutsensingmembranefluidity AT dorithwunnicke regulationoflipidsaturationwithoutsensingmembranefluidity AT ingahanelt regulationoflipidsaturationwithoutsensingmembranefluidity AT ilyalevental regulationoflipidsaturationwithoutsensingmembranefluidity AT gerhardhummer regulationoflipidsaturationwithoutsensingmembranefluidity AT roberternst regulationoflipidsaturationwithoutsensingmembranefluidity
_version_	1721450782059921408

Regulation of lipid saturation without sensing membrane fluidity

Similar Items