Cyclosporin A reduces airway mucus secretion and mucociliary clearance in rats Ciclosporina A reduz a secreção de muco das vias aéreas e o transporte mucociliar de ratos

Cyclosporin A reduces airway mucus secretion and mucociliary clearance in rats Ciclosporina A reduz a secreção de muco das vias aéreas e o transporte mucociliar de ratos

PURPOSE: To assay the effects of cyclosporin A on mucus secretion from goblet cells and on mucociliary transport in situ in rats. METHODS: Twenty-one male Wistar rats were assigned to 3 groups: control (n = 5), saline (n = 8), and cyclosporin A (n = 8). After 30 days of drug therapy, the rats were k...

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Bibliographic Details
Main Authors: Rogerio Pazetti, Paulo Manuel Pego-Fernandes, Otavio Tavares Ranzani, Edwin Roger Parra, Geraldo Lorenzi-Filho, Fabio B. Jatene
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2007-01-01
Series:Clinics
Subjects:
Ciclosporina
Transporte mucociliar
Célula caliciforme
Mucinas
Cyclosporine
Mucociliary clearance
Goblet cell
Mucin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322007000300021

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322007000300021

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