Evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiency
Objective. To study proinflammatory cytokines and brain natriuretic peptide (BNP) in patients with rheumatic heart diseases (RHD) and coronary heart disease (CHD) complicated by chronic heart insufficiency (CHI). Material and methods. 54 pts with CHI (among them 16 with RHD and 38 with CHD with sign...
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doaj-71925fb68f044213a2e0cd13838b7e0e2021-08-02T09:05:35ZrusIMA-PRESS LLCНаучно-практическая ревматология1995-44841995-44922005-04-01432252810.14412/1995-4484-2005-15201266Evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiencyN A ShoslakA S PoskrebyshevaA A KopylovaObjective. To study proinflammatory cytokines and brain natriuretic peptide (BNP) in patients with rheumatic heart diseases (RHD) and coronary heart disease (CHD) complicated by chronic heart insufficiency (CHI). Material and methods. 54 pts with CHI (among them 16 with RHD and 38 with CHD with signs of CHI ofll-IV functional class according to NYHA that correspond to 11A-III stage according to N.D. Strazesko-V.H. \frsilenko classification) and 30 healthy persons of control group were examined. Besides clinical evaluation common laboratory and instrumental methods were used. Thorough echocardiography analysis, quantitative evaluation of serum TNF a, IL6 and BNP by immuno-enzyme assay was performed. Results. Direct correlation between cytokines and BNP levels and pts with CHI clinical state severity was revealed. These indiccs significantly differed in coronary and non-coronary (RHD) CHI. TNF a concentration was minimal in mitral stenosis. Maximal concentrations of IL6 and TNF a were revealed in tricuspid regurgitation. TNF a concentration elevated with increase of heart linear dimensions. BNP showed similar but less prominent tendencies. Conclusion. Significant difference of studied indices in coronary and non-coronary (RHD) CHI was shown. Despite of similarity of CHI clinical features levels of inflammation biological indices in RHD was significantly lower than in CHD that requires further discussion.https://rsp.mediar-press.net/rsp/article/view/1326rheumatic heart diseaseschronic heart insufficiencytumor necrosis factor ainterleukin 6brain natriuretic peptide |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
N A Shoslak A S Poskrebysheva A A Kopylova |
spellingShingle |
N A Shoslak A S Poskrebysheva A A Kopylova Evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiency Научно-практическая ревматология rheumatic heart diseases chronic heart insufficiency tumor necrosis factor a interleukin 6 brain natriuretic peptide |
author_facet |
N A Shoslak A S Poskrebysheva A A Kopylova |
author_sort |
N A Shoslak |
title |
Evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiency |
title_short |
Evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiency |
title_full |
Evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiency |
title_fullStr |
Evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiency |
title_full_unstemmed |
Evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiency |
title_sort |
evaluation of proinflammatory cytokines and brain natriuretic peptide in patients with rheumatic heart diseases and coronary heart disease complicated by chronic heart insufficiency |
publisher |
IMA-PRESS LLC |
series |
Научно-практическая ревматология |
issn |
1995-4484 1995-4492 |
publishDate |
2005-04-01 |
description |
Objective. To study proinflammatory cytokines and brain natriuretic peptide (BNP) in patients with rheumatic heart diseases (RHD) and coronary heart disease (CHD) complicated by chronic heart insufficiency (CHI). Material and methods. 54 pts with CHI (among them 16 with RHD and 38 with CHD with signs of CHI ofll-IV functional class according to NYHA that correspond to 11A-III stage according to N.D. Strazesko-V.H. \frsilenko classification) and 30 healthy persons of control group were examined. Besides clinical evaluation common laboratory and instrumental methods were used. Thorough echocardiography analysis, quantitative evaluation of serum TNF a, IL6 and BNP by immuno-enzyme assay was performed. Results. Direct correlation between cytokines and BNP levels and pts with CHI clinical state severity was revealed. These indiccs significantly differed in coronary and non-coronary (RHD) CHI. TNF a concentration was minimal in mitral stenosis. Maximal concentrations of IL6 and TNF a were revealed in tricuspid regurgitation. TNF a concentration elevated with increase of heart linear dimensions. BNP showed similar but less prominent tendencies. Conclusion. Significant difference of studied indices in coronary and non-coronary (RHD) CHI was shown. Despite of similarity of CHI clinical features levels of inflammation biological indices in RHD was significantly lower than in CHD that requires further discussion. |
topic |
rheumatic heart diseases chronic heart insufficiency tumor necrosis factor a interleukin 6 brain natriuretic peptide |
url |
https://rsp.mediar-press.net/rsp/article/view/1326 |
work_keys_str_mv |
AT nashoslak evaluationofproinflammatorycytokinesandbrainnatriureticpeptideinpatientswithrheumaticheartdiseasesandcoronaryheartdiseasecomplicatedbychronicheartinsufficiency AT asposkrebysheva evaluationofproinflammatorycytokinesandbrainnatriureticpeptideinpatientswithrheumaticheartdiseasesandcoronaryheartdiseasecomplicatedbychronicheartinsufficiency AT aakopylova evaluationofproinflammatorycytokinesandbrainnatriureticpeptideinpatientswithrheumaticheartdiseasesandcoronaryheartdiseasecomplicatedbychronicheartinsufficiency |
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1721236174000881664 |