SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling

SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling

Diffuse-type gastric carcinoma (DGC) exhibits aggressive progression associated with rapid infiltrative growth, massive fibrosis, and peritoneal dissemination. Gene amplification of Met and fibroblast growth factor receptor 2 (FGFR2) receptor tyrosine kinases (RTKs) has been observed in DGC. However...

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Bibliographic Details
Main Authors: Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Arata Tomiyama, Rieko Ohki, Kazuyoshi Yanagihara, Ryuichi Sakai, Hideki Yamaguchi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
diffuse-type gastric carcinoma
peritoneal dissemination
SHP2
receptor tyrosine kinase
Met
Online Access:https://www.mdpi.com/2072-6694/13/17/4309

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