The Chloride Anion Acts as a Second Messenger in Mammalian Cells - Modifying the Expression of Specific Genes

Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the expression of several genes can be modulated by the CFTR activity; among them, SRC, MTND4, CISD1, and IL1B. However, the CFTR sign...

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Bibliographic Details
Main Authors: Ángel G. Valdivieso, Mariángeles Clauzure, Macarena Massip-Copiz, Tomás A. Santa-Coloma
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Online Access:http://www.karger.com/Article/FullText/438608