Sellar chondroid chordoma

• Main Authors: Xia LI, Qing LI, Ying-mei WANG, Li-ying ZHANG, Yu GU
• Format: Article
• Language: English
• Published: Tianjin Huanhu Hospital 2014-02-01
• Series: Chinese Journal of Contemporary Neurology and Neurosurgery
• Subjects: Chordoma; Chondrocytes; Sella turcica; Immunohistochemistry
• Online Access: http://www.cjcnn.org/index.php/cjcnn/article/view/895

<p><strong>Objective</strong> To investigate the clinical and pathological characteristics of sellar chondroid chordoma and discuss differential diagnosis of sellar chondroid chordoma with literature review. <strong>Methods</strong> The clinical manifestations of a patient with chondroid chordoma occurring in sellar area were stated. The morphological characteristics and immune phenotype were analyzed by using HE and immunohistochemical staining, and related literatures were reviewed. <strong>Results</strong> A 66-year-old male mainly presented with repeated hyponatremia. MRI revealed a well-circumscribed, round and space-occupying mass in sellar area. The tumor was removed under endoscope via the right nasal cavity. During the resection, the tumor could be seen locating in sellar region with solid, tough quality and clear boundaries. Histologically, part of the tumor showed the chondroid differentiation in classical chordoma. The immunohistochemistry of this tumor was positive for cytokeratin (CK), epithelial membrane antigen (EMA) and S-100 protein (S-100), and Ki-67 labeling index was about 1%. The pathological diagnosis was sellar chondroid chordoma. During the follow-up period of 11 months, the patient was in good condition and no tumor recurrence was found. <strong>Conclusions</strong> Despite low incidence, chondroid chordoma usually develops in the midline regions with distinctive histological features and immunohistochemical phenotypes. In general, the prognosis is better than general type of chordoma, and the diagnosis should be differentiated from general types of chordoma and chondrosarcoma.</p><p>doi：10.3969/j.issn.1672-6731.2014.02.007</p>