Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis
The rate of diagnosis of colonization/infection of the airways with Achromobacter xylosoxidans has increased in cystic fibrosis patients, but its clinical significance is still controversial. This retrospective, case-control study aimed to evaluate the clinical impact of A. xylosoxidans colonization...
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doaj-71adaa5122974b0eaf9a5519e5d8e5642020-11-25T00:11:53ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2016-01-0149410.1590/1414-431X20155097S0100-879X2016000400703Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosisM.C. FirmidaR.H.V. PereiraE.A.S.R. SilvaE.A. MarquesA.J. LopesThe rate of diagnosis of colonization/infection of the airways with Achromobacter xylosoxidans has increased in cystic fibrosis patients, but its clinical significance is still controversial. This retrospective, case-control study aimed to evaluate the clinical impact of A. xylosoxidans colonization/infection in cystic fibrosis patients. Individuals who were chronically colonized/infected (n=10), intermittently colonized/infected (n=15), and never colonized/infected with A. xylosoxidans (n=18) were retrospectively evaluated during two periods that were 2 years apart. Demographic characteristics, clinical data, lung function, and chronic bacterial co-colonization data were evaluated. Of the total study population, 87% were pediatric patients and 65.1% were female. Individuals chronically colonized/infected with A. xylosoxidans had decreased forced expiratory volume in 1 s (51.7% in the chronic colonization/infection group vs 82.7% in the intermittent colonization/infection group vs 76% in the never colonized/infected group). Compared with the other two groups, the rate of co-colonization with methicillin-resistant Staphylococcus aureus was higher in individuals chronically colonized/infected with A. xylosoxidans (P=0.002). Changes in lung function over 2 years in the three groups were not significant, although a trend toward a greater decrease in lung function was observed in the chronically colonized/infected group. Compared with the other two groups, there was a greater number of annual hospitalizations in patients chronically colonized/infected with A. xylosoxidans (P=0.033). In cystic fibrosis patients, there was an increased frequency of A. xylosoxidans colonization/infection in children, and lung function was reduced in patients who were chronically colonized/infected with A. xylosoxidans. Additionally, there were no differences in clinical outcomes during the 2-year period, except for an increased number of hospitalizations in patients with A. xylosoxidans.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400703&lng=en&tlng=enCystic fibrosisAchromobacter spp.Achromobacter xylosoxidansMicrobiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M.C. Firmida R.H.V. Pereira E.A.S.R. Silva E.A. Marques A.J. Lopes |
spellingShingle |
M.C. Firmida R.H.V. Pereira E.A.S.R. Silva E.A. Marques A.J. Lopes Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis Brazilian Journal of Medical and Biological Research Cystic fibrosis Achromobacter spp. Achromobacter xylosoxidans Microbiology |
author_facet |
M.C. Firmida R.H.V. Pereira E.A.S.R. Silva E.A. Marques A.J. Lopes |
author_sort |
M.C. Firmida |
title |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_short |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_full |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_fullStr |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_full_unstemmed |
Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
title_sort |
clinical impact of achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
1414-431X |
publishDate |
2016-01-01 |
description |
The rate of diagnosis of colonization/infection of the airways with Achromobacter xylosoxidans has increased in cystic fibrosis patients, but its clinical significance is still controversial. This retrospective, case-control study aimed to evaluate the clinical impact of A. xylosoxidans colonization/infection in cystic fibrosis patients. Individuals who were chronically colonized/infected (n=10), intermittently colonized/infected (n=15), and never colonized/infected with A. xylosoxidans (n=18) were retrospectively evaluated during two periods that were 2 years apart. Demographic characteristics, clinical data, lung function, and chronic bacterial co-colonization data were evaluated. Of the total study population, 87% were pediatric patients and 65.1% were female. Individuals chronically colonized/infected with A. xylosoxidans had decreased forced expiratory volume in 1 s (51.7% in the chronic colonization/infection group vs 82.7% in the intermittent colonization/infection group vs 76% in the never colonized/infected group). Compared with the other two groups, the rate of co-colonization with methicillin-resistant Staphylococcus aureus was higher in individuals chronically colonized/infected with A. xylosoxidans (P=0.002). Changes in lung function over 2 years in the three groups were not significant, although a trend toward a greater decrease in lung function was observed in the chronically colonized/infected group. Compared with the other two groups, there was a greater number of annual hospitalizations in patients chronically colonized/infected with A. xylosoxidans (P=0.033). In cystic fibrosis patients, there was an increased frequency of A. xylosoxidans colonization/infection in children, and lung function was reduced in patients who were chronically colonized/infected with A. xylosoxidans. Additionally, there were no differences in clinical outcomes during the 2-year period, except for an increased number of hospitalizations in patients with A. xylosoxidans. |
topic |
Cystic fibrosis Achromobacter spp. Achromobacter xylosoxidans Microbiology |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400703&lng=en&tlng=en |
work_keys_str_mv |
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