INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS

INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS

Neuronal synaptic contacts are among the basic elements that determine the plasticity of the nervous system. Changes in the efficiency of synaptic transmission mediate sensation, conduction of excitation, learning, and memory. Dendritic spines are the postsynaptic part of excitatory synapses in high...

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Main Authors: A. L. Proskura, I. A. Malachin, T. A. Zapara, I. I. Turnaev, V. V. Suslov, A. S. Ratuschnyak
Format: Article
Language:English
Published: Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2015-01-01
Series:Vavilovskij Žurnal Genetiki i Selekcii
Subjects:
synaptic plasticity
long-term potentiation
glutamate receptors
Online Access:https://vavilov.elpub.ru/jour/article/view/186
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spelling doaj-71b320b6200e47cca4b74718d44b564e2021-09-11T08:41:14ZengInstitute of Cytology and Genetics of Siberian Branch of the Russian Academy of SciencesVavilovskij Žurnal Genetiki i Selekcii2500-04622500-32592015-01-01174/1620628170INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMSA. L. Proskura0I. A. Malachin1T. A. Zapara2I. I. Turnaev3V. V. Suslov4A. S. Ratuschnyak5Design Technological Institute of Digital Techniques SB RAS, Novosibirsk, RussiaDesign Technological Institute of Digital Techniques SB RAS, Novosibirsk, RussiaDesign Technological Institute of Digital Techniques SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaDesign Technological Institute of Digital Techniques SB RAS, Novosibirsk, RussiaNeuronal synaptic contacts are among the basic elements that determine the plasticity of the nervous system. Changes in the efficiency of synaptic transmission mediate sensation, conduction of excitation, learning, and memory. Dendritic spines are the postsynaptic part of excitatory synapses in higher divisions of mammalian brains. Protein–protein networks of spine microdomains form the functional system of neuronal synapses. Reconstruction of the conceptual model of molecular interactions has been performed. The model represents activity-dependent changes of the synaptic transmission efficiency, integration of excitation in the local dendritic network of a neuron, and prolonged maintenance of the new level of neurotransmission.https://vavilov.elpub.ru/jour/article/view/186synaptic plasticitylong-term potentiationglutamate receptors
collection DOAJ
language English
format Article
sources DOAJ
author A. L. Proskura
I. A. Malachin
T. A. Zapara
I. I. Turnaev
V. V. Suslov
A. S. Ratuschnyak
spellingShingle A. L. Proskura
I. A. Malachin
T. A. Zapara
I. I. Turnaev
V. V. Suslov
A. S. Ratuschnyak
INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS
Vavilovskij Žurnal Genetiki i Selekcii
synaptic plasticity
long-term potentiation
glutamate receptors
author_facet A. L. Proskura
I. A. Malachin
T. A. Zapara
I. I. Turnaev
V. V. Suslov
A. S. Ratuschnyak
author_sort A. L. Proskura
title INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS
title_short INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS
title_full INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS
title_fullStr INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS
title_full_unstemmed INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS
title_sort intermolecular interactions in neuronal functional systems
publisher Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences
series Vavilovskij Žurnal Genetiki i Selekcii
issn 2500-0462
2500-3259
publishDate 2015-01-01
description Neuronal synaptic contacts are among the basic elements that determine the plasticity of the nervous system. Changes in the efficiency of synaptic transmission mediate sensation, conduction of excitation, learning, and memory. Dendritic spines are the postsynaptic part of excitatory synapses in higher divisions of mammalian brains. Protein–protein networks of spine microdomains form the functional system of neuronal synapses. Reconstruction of the conceptual model of molecular interactions has been performed. The model represents activity-dependent changes of the synaptic transmission efficiency, integration of excitation in the local dendritic network of a neuron, and prolonged maintenance of the new level of neurotransmission.
topic synaptic plasticity
long-term potentiation
glutamate receptors
url https://vavilov.elpub.ru/jour/article/view/186
work_keys_str_mv AT alproskura intermolecularinteractionsinneuronalfunctionalsystems
AT iamalachin intermolecularinteractionsinneuronalfunctionalsystems
AT tazapara intermolecularinteractionsinneuronalfunctionalsystems
AT iiturnaev intermolecularinteractionsinneuronalfunctionalsystems
AT vvsuslov intermolecularinteractionsinneuronalfunctionalsystems
AT asratuschnyak intermolecularinteractionsinneuronalfunctionalsystems
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