Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity, selectivity and signal strength. One importa...
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doaj-71b7abc96c584b0c9f709b6eaad804c22020-11-24T23:26:29ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252018-05-01522910.3390/jcdd5020029jcdd5020029Functional Significance of the Adcy10-Dependent Intracellular cAMP CompartmentsSofya Pozdniakova0Yury Ladilov1Institute of Gender in Medicine, Center for Cardiovascular Research, Charite, 10115 Berlin, GermanyInstitute of Gender in Medicine, Center for Cardiovascular Research, Charite, 10115 Berlin, GermanyMounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity, selectivity and signal strength. One important player in cAMP signaling is soluble adenylyl cyclase (sAC). The intracellular localization of sAC allows for the formation of unique intracellular cAMP microdomains that control various physiological and pathological processes. This review is focused on the functional role of sAC-produced cAMP. In particular, we examine the role of sAC-cAMP in different cellular compartments, such as cytosol, nucleus and mitochondria.http://www.mdpi.com/2308-3425/5/2/29adcy10cAMPphosphodiesterasecompartmentalization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sofya Pozdniakova Yury Ladilov |
spellingShingle |
Sofya Pozdniakova Yury Ladilov Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments Journal of Cardiovascular Development and Disease adcy10 cAMP phosphodiesterase compartmentalization |
author_facet |
Sofya Pozdniakova Yury Ladilov |
author_sort |
Sofya Pozdniakova |
title |
Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments |
title_short |
Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments |
title_full |
Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments |
title_fullStr |
Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments |
title_full_unstemmed |
Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments |
title_sort |
functional significance of the adcy10-dependent intracellular camp compartments |
publisher |
MDPI AG |
series |
Journal of Cardiovascular Development and Disease |
issn |
2308-3425 |
publishDate |
2018-05-01 |
description |
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity, selectivity and signal strength. One important player in cAMP signaling is soluble adenylyl cyclase (sAC). The intracellular localization of sAC allows for the formation of unique intracellular cAMP microdomains that control various physiological and pathological processes. This review is focused on the functional role of sAC-produced cAMP. In particular, we examine the role of sAC-cAMP in different cellular compartments, such as cytosol, nucleus and mitochondria. |
topic |
adcy10 cAMP phosphodiesterase compartmentalization |
url |
http://www.mdpi.com/2308-3425/5/2/29 |
work_keys_str_mv |
AT sofyapozdniakova functionalsignificanceoftheadcy10dependentintracellularcampcompartments AT yuryladilov functionalsignificanceoftheadcy10dependentintracellularcampcompartments |
_version_ |
1725554998229598208 |