Modulation effect of blu-ray irradiation combined with comprehensive therapy on serum indexes of neonatal erythrocyte glucose-6-phosphate dehydrogenase deficiency-induced hyperbilirubinemia
Objective: To study the modulation effect of blu-ray irradiation combined with comprehensive therapy on serum indexes of neonatal erythrocyte glucose-6-phosphate dehydrogenase deficiency-induced hyperbilirubinemia. Methods: A total of 42 cases of neonates with erythrocyte glucose-6-phosphate dehy...
Main Author: | |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2016-01-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201602/26.pdf |
Summary: | Objective: To study the modulation effect of blu-ray irradiation combined with comprehensive
therapy on serum indexes of neonatal erythrocyte glucose-6-phosphate dehydrogenase
deficiency-induced hyperbilirubinemia. Methods: A total of 42 cases of neonates with
erythrocyte glucose-6-phosphate dehydrogenase deficiency-induced hyperbilirubinemia were
chosen for study and randomly divided into observation group (n=21) and control group (n=21).
Observation group received blu-ray irradiation combined with comprehensive treatment and
control group only received routine treatment. Then bilirubin levels, bilirubin encephalopathy
condition, anemia condition and oxidative stress degree of two groups were compared.
Results: 12 h, 24 h and 48 h after treatment, serum TBIL, DBIL, IBIL, Hb, GSH and CAT
contents of both groups showed decreasing trend and MDA contents showed increasing trend;
serum TBIL, DBIL, IBIL, Hb, GSH and CAT contents of observation group were lower than
those of control group and MDA contents were higher than those of control group. 6 d, 7 d and
8 d after treatment, serum S100 β and NSE contents of both groups showed decreasing trend
and serum S100 β and NSE contents of observation group were lower than those of control
group. Conclusion: Blu-ray irradiation combined with comprehensive therapy helps to reduce
bilirubin levels of neonatal erythrocyte glucose-6-phosphate dehydrogenase deficiency-induced
hyperbilirubinemia and protect nerve function, but it will aggravate anemia condition and
oxidative stress degree, and needs attention and intervention in clinical practice. |
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ISSN: | 1007-1237 1007-1237 |