A COMPARATIVE STUDY OF DRUG RELEASE FROM POLYCOMPLEX MATRICES IN STANDARD AND BIORELEVANT MEDIA USING USP III AND USP IV APPARATUS
The results of Indomethacin release from the oral drug delivery systems based on interpolymer complexes with Eudragit® copolymers are presented. The release assessment was performed by two methods - flow-through cell (USP IV Apparatus) and the reciprocating cylinder (USP III Apparatus) in standard b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/333 |
| Summary: | The results of Indomethacin release from the oral drug delivery systems based on interpolymer complexes with Eudragit® copolymers are presented. The release assessment was performed by two methods - flow-through cell (USP IV Apparatus) and the reciprocating cylinder (USP III Apparatus) in standard buffer solutions and biorelevant media. The release of indomethacin can be described as "intestinal" type. According to the results Indomethacin was released faster using USP III Apparatus due to stress-effect on the erosion type matrices. |
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| ISSN: | 2305-2066 2658-5049 |