Effect of Qingre Yangyin Humo prescription on serum indexes in esophageal cancer radiotherapy
Objective: To study the effectiveness of Qingre Yangyin Humo prescription in preventing radioaction esophagitis and its effect on the serum radiation damage indexes. Methods: Patients with advanced esophageal cancer who received radiotherapy in the First Affiliated Hospital of Bengbu Medical Coll...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-06-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201712/28.pdf |
Summary: | Objective: To study the effectiveness of Qingre Yangyin Humo prescription in preventing
radioaction esophagitis and its effect on the serum radiation damage indexes. Methods:
Patients with advanced esophageal cancer who received radiotherapy in the First Affiliated
Hospital of Bengbu Medical College between June 2015 and December 2016 were selected as
the research subjects and randomly divided into two groups, the intervention group received
Qingre Yangyin Humo prescription during radiotherapy, and the control group received regular
intervention during radiotherapy. The incidence of radiation esophagitis within 90 days after
radiotherapy was observed, and serum inflammation indexes, oxidative stress indexes and
pulmonary fibrosis index were determined before radiotherapy as well as 2 weeks and 4 weeks
after radiotherapy. Results: After radiotherapy, serum TNF-α, IL-1β, IL-6, IL-8, MDA,
8-OHdG, MMP9, TGF-β1 and ACE levels of both groups were significantly higher than those
before radiotherapy while GPX1, T-SOD and Mn-SOD levels were significantly lower than
those before radiotherapy, and serum TNF-α, IL-1β, IL-6, IL-8, MDA, 8-OHdG, MMP9,
TGF-β1 and ACE levels of intervention group were significantly lower than those of control
group while GPX1, T-SOD and Mn-SOD levels were significantly higher than those of control
group. Conclusion: Qingre Yangyin Humo prescription can prevent the occurrence of radiation
esophagitis and reduce radiation damage during radiotherapy. |
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ISSN: | 1007-1237 1007-1237 |