Effect of Qingre Yangyin Humo prescription on serum indexes in esophageal cancer radiotherapy

• Main Authors: Yu-Fu Zhou1, Ya-Jun Zhang1, Qian Sun1, Geng-Ming Wang1, Tao Qi1, Yan Zhou1, Bang-Ling Chen2, Lan Zhou3
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-06-01
• Series: Journal of Hainan Medical University
• Subjects: Esophageal cancer Radiotherapy Radiation esophagitis Inflammation Oxidative stress
• Online Access: http://www.hnykdxxb.com/PDF/201712/28.pdf

Objective: To study the effectiveness of Qingre Yangyin Humo prescription in preventing radioaction esophagitis and its effect on the serum radiation damage indexes. Methods: Patients with advanced esophageal cancer who received radiotherapy in the First Affiliated Hospital of Bengbu Medical College between June 2015 and December 2016 were selected as the research subjects and randomly divided into two groups, the intervention group received Qingre Yangyin Humo prescription during radiotherapy, and the control group received regular intervention during radiotherapy. The incidence of radiation esophagitis within 90 days after radiotherapy was observed, and serum inflammation indexes, oxidative stress indexes and pulmonary fibrosis index were determined before radiotherapy as well as 2 weeks and 4 weeks after radiotherapy. Results: After radiotherapy, serum TNF-α, IL-1β, IL-6, IL-8, MDA, 8-OHdG, MMP9, TGF-β1 and ACE levels of both groups were significantly higher than those before radiotherapy while GPX1, T-SOD and Mn-SOD levels were significantly lower than those before radiotherapy, and serum TNF-α, IL-1β, IL-6, IL-8, MDA, 8-OHdG, MMP9, TGF-β1 and ACE levels of intervention group were significantly lower than those of control group while GPX1, T-SOD and Mn-SOD levels were significantly higher than those of control group. Conclusion: Qingre Yangyin Humo prescription can prevent the occurrence of radiation esophagitis and reduce radiation damage during radiotherapy.