Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets

Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets

This study investigates for the first time the crosstalk between stromal fibroblasts and cancer stem cell (CSC) biology in head and neck squamous cell carcinomas (HNSCC), with the ultimate goal of identifying effective therapeutic targets. The effects of conditioned media from cancer-associated fibr...

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Bibliographic Details
Main Authors: Saúl Álvarez-Teijeiro, Cristina García-Inclán, M. Ángeles Villaronga, Pedro Casado, Francisco Hermida-Prado, Rocío Granda-Díaz, Juan P. Rodrigo, Fernando Calvo, Nagore del-Río-Ibisate, Alberto Gandarillas, Francisco Morís, Mario Hermsen, Pedro Cutillas, Juana M. García-Pedrero
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
head and neck squamous cell carcinoma
cancer-associated fibroblasts
cancer stem cells
tumor microenvironment
secretome
therapeutic target
Online Access:http://www.mdpi.com/2072-6694/10/9/334

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http://www.mdpi.com/2072-6694/10/9/334

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