EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies
Introduction Congenital anomalies (CAs) are a major cause of infant mortality, childhood morbidity and long-term disability. Over 130 000 children born in Europe every year will have a CA. This paper describes the EUROlinkCAT study, which is investigating the health and educational outcomes of child...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2021-06-01
|
Series: | BMJ Open |
Online Access: | https://bmjopen.bmj.com/content/11/6/e047859.full |
id |
doaj-71d0d10a7c8340b8864daf7f71f7e0a9 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nathalie Lelong Babak Khoshnood David Tucker Mika Gissler Maria Loane Ingeborg Barisic Miriam Gatt Kari Klungsoyr Amanda Neville Anna Pierini Anke Rissmann Oscar Zurriaga Joan K Morris Paula Braz Vera Nelen Judith Rankin Ester Garne Sue Jordan Anna Heino Silvia Baldacci Michele Santoro Alessio Coi Lorena Mezzasalma Daniel Thayer Svetlana V Glinianaia Hermien de Walle Guy Thys Anna Latos-Bielenska Aurora Puccini Elisa Ballardini Wladimir Wertelecki Carlos Matias Dias Gianni Astolfi James Densem Joachim Tan Joanne Emma Given Hugh Claridge Abigail Reid Liz Limb Gillian Briggs Nicholas Connor Stine Kjaer Urhoj Mads Damkjær Christina Neergaard Pedersen Annarita Armaroli Ljubica Boban L Renée Lutke Nicole H A Siemensma-Mühlenberg Nathalie Bertille Makan Rahshenas Clara Cavero Carbonell Laia Barrachina Bonet Laura García Villodre Anna Jamry-Dziurla Sonja Kiuru-Kuhlefelt Lyubov Yevtushok Nataliia Zymak-Zakutnia Diana Akhmedzhanova Lyubov Ostapchuk Oksana Tsizh Serhii Lapchenko Ausenda Machado Ana João Santos Liliana Antunes Hanitra Randrianaivo-Ranjatoelina Elly Den Hond Olatz Mokoroa Carollo Ieuan Scanlon |
spellingShingle |
Nathalie Lelong Babak Khoshnood David Tucker Mika Gissler Maria Loane Ingeborg Barisic Miriam Gatt Kari Klungsoyr Amanda Neville Anna Pierini Anke Rissmann Oscar Zurriaga Joan K Morris Paula Braz Vera Nelen Judith Rankin Ester Garne Sue Jordan Anna Heino Silvia Baldacci Michele Santoro Alessio Coi Lorena Mezzasalma Daniel Thayer Svetlana V Glinianaia Hermien de Walle Guy Thys Anna Latos-Bielenska Aurora Puccini Elisa Ballardini Wladimir Wertelecki Carlos Matias Dias Gianni Astolfi James Densem Joachim Tan Joanne Emma Given Hugh Claridge Abigail Reid Liz Limb Gillian Briggs Nicholas Connor Stine Kjaer Urhoj Mads Damkjær Christina Neergaard Pedersen Annarita Armaroli Ljubica Boban L Renée Lutke Nicole H A Siemensma-Mühlenberg Nathalie Bertille Makan Rahshenas Clara Cavero Carbonell Laia Barrachina Bonet Laura García Villodre Anna Jamry-Dziurla Sonja Kiuru-Kuhlefelt Lyubov Yevtushok Nataliia Zymak-Zakutnia Diana Akhmedzhanova Lyubov Ostapchuk Oksana Tsizh Serhii Lapchenko Ausenda Machado Ana João Santos Liliana Antunes Hanitra Randrianaivo-Ranjatoelina Elly Den Hond Olatz Mokoroa Carollo Ieuan Scanlon EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies BMJ Open |
author_facet |
Nathalie Lelong Babak Khoshnood David Tucker Mika Gissler Maria Loane Ingeborg Barisic Miriam Gatt Kari Klungsoyr Amanda Neville Anna Pierini Anke Rissmann Oscar Zurriaga Joan K Morris Paula Braz Vera Nelen Judith Rankin Ester Garne Sue Jordan Anna Heino Silvia Baldacci Michele Santoro Alessio Coi Lorena Mezzasalma Daniel Thayer Svetlana V Glinianaia Hermien de Walle Guy Thys Anna Latos-Bielenska Aurora Puccini Elisa Ballardini Wladimir Wertelecki Carlos Matias Dias Gianni Astolfi James Densem Joachim Tan Joanne Emma Given Hugh Claridge Abigail Reid Liz Limb Gillian Briggs Nicholas Connor Stine Kjaer Urhoj Mads Damkjær Christina Neergaard Pedersen Annarita Armaroli Ljubica Boban L Renée Lutke Nicole H A Siemensma-Mühlenberg Nathalie Bertille Makan Rahshenas Clara Cavero Carbonell Laia Barrachina Bonet Laura García Villodre Anna Jamry-Dziurla Sonja Kiuru-Kuhlefelt Lyubov Yevtushok Nataliia Zymak-Zakutnia Diana Akhmedzhanova Lyubov Ostapchuk Oksana Tsizh Serhii Lapchenko Ausenda Machado Ana João Santos Liliana Antunes Hanitra Randrianaivo-Ranjatoelina Elly Den Hond Olatz Mokoroa Carollo Ieuan Scanlon |
author_sort |
Nathalie Lelong |
title |
EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies |
title_short |
EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies |
title_full |
EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies |
title_fullStr |
EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies |
title_full_unstemmed |
EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies |
title_sort |
eurolinkcat protocol for a european population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies |
publisher |
BMJ Publishing Group |
series |
BMJ Open |
issn |
2044-6055 |
publishDate |
2021-06-01 |
description |
Introduction Congenital anomalies (CAs) are a major cause of infant mortality, childhood morbidity and long-term disability. Over 130 000 children born in Europe every year will have a CA. This paper describes the EUROlinkCAT study, which is investigating the health and educational outcomes of children with CAs for the first 10 years of their lives.Methods and analysis EUROCAT is a European network of population-based registries for the epidemiological surveillance of CAs. EUROlinkCAT is using the EUROCAT infrastructure to support 22 EUROCAT registries in 14 countries to link their data on births with CAs to mortality, hospital discharge, prescription and educational databases. Once linked, each registry transforms their case data into a common data model (CDM) format and they are then supplied with common STATA syntax scripts to analyse their data. The resulting aggregate tables and analysis results are submitted to a central results repository (CRR) and meta-analyses are performed to summarise the results across all registries. The CRR currently contains data on 155 594 children with a CA followed up to age 10 from a population of 6 million births from 1995 to 2014.Ethics The CA registries have the required ethics permissions for routine surveillance and transmission of anonymised data to the EUROCAT central database. Each registry is responsible for applying for and obtaining additional ethics and other permissions required for their participation in EUROlinkCAT.Dissemination The CDM and associated documentation, including linkage and standardisation procedures, will be available post-EUROlinkCAT thus facilitating future local, national and European-level analyses to improve healthcare. Recommendations to improve the accuracy of routinely collected data will be made.Findings will provide evidence to inform parents, health professionals, public health authorities and national treatment guidelines to optimise diagnosis, prevention and treatment for these children with a view to reducing health inequalities in Europe. |
url |
https://bmjopen.bmj.com/content/11/6/e047859.full |
work_keys_str_mv |
AT nathalielelong eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT babakkhoshnood eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT davidtucker eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT mikagissler eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT marialoane eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT ingeborgbarisic eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT miriamgatt eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT kariklungsoyr eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT amandaneville eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT annapierini eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT ankerissmann eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT oscarzurriaga eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT joankmorris eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT paulabraz eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT veranelen eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT judithrankin eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT estergarne eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT suejordan eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT annaheino eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT silviabaldacci eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT michelesantoro eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT alessiocoi eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT lorenamezzasalma eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT danielthayer eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT svetlanavglinianaia eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT hermiendewalle eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT guythys eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT annalatosbielenska eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT aurorapuccini eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT elisaballardini eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT wladimirwertelecki eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT carlosmatiasdias eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT gianniastolfi eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT jamesdensem eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT joachimtan eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT joanneemmagiven eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT hughclaridge eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT abigailreid eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT lizlimb eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT gillianbriggs eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT nicholasconnor eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT stinekjaerurhoj eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT madsdamkjær eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT christinaneergaardpedersen eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT annaritaarmaroli eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT ljubicaboban eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT lreneelutke eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT nicolehasiemensmamuhlenberg eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT nathaliebertille eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT makanrahshenas eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT claracaverocarbonell eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT laiabarrachinabonet eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT lauragarciavillodre eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT annajamrydziurla eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT sonjakiurukuhlefelt eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT lyubovyevtushok eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT nataliiazymakzakutnia eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT dianaakhmedzhanova eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT lyubovostapchuk eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT oksanatsizh eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT serhiilapchenko eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT ausendamachado eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT anajoaosantos eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT lilianaantunes eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT hanitrarandrianaivoranjatoelina eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT ellydenhond eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT olatzmokoroacarollo eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies AT ieuanscanlon eurolinkcatprotocolforaeuropeanpopulationbaseddatalinkagestudyinvestigatingthesurvivalmorbidityandeducationofchildrenwithcongenitalanomalies |
_version_ |
1721216842311139328 |
spelling |
doaj-71d0d10a7c8340b8864daf7f71f7e0a92021-08-07T17:03:17ZengBMJ Publishing GroupBMJ Open2044-60552021-06-0111610.1136/bmjopen-2020-047859EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomaliesNathalie LelongBabak KhoshnoodDavid Tucker0Mika Gissler1Maria Loane2Ingeborg Barisic3Miriam Gatt4Kari KlungsoyrAmanda Neville5Anna Pierini6Anke Rissmann7Oscar ZurriagaJoan K Morris8Paula BrazVera Nelen9Judith Rankin10Ester Garne11Sue Jordan12Anna HeinoSilvia BaldacciMichele SantoroAlessio CoiLorena MezzasalmaDaniel ThayerSvetlana V GlinianaiaHermien de Walle13Guy ThysAnna Latos-Bielenska14Aurora PucciniElisa BallardiniWladimir WerteleckiCarlos Matias DiasGianni AstolfiJames Densem15Joachim Tan16Joanne Emma Given17Hugh Claridge18Abigail ReidLiz LimbGillian BriggsNicholas ConnorStine Kjaer UrhojMads DamkjærChristina Neergaard PedersenAnnarita ArmaroliLjubica BobanL Renée LutkeNicole H A Siemensma-MühlenbergNathalie BertilleMakan RahshenasClara Cavero CarbonellLaia Barrachina BonetLaura García VillodreAnna Jamry-DziurlaSonja Kiuru-KuhlefeltLyubov YevtushokNataliia Zymak-ZakutniaDiana AkhmedzhanovaLyubov OstapchukOksana TsizhSerhii LapchenkoAusenda MachadoAna João SantosLiliana AntunesHanitra Randrianaivo-RanjatoelinaElly Den HondOlatz Mokoroa CarolloIeuan ScanlonCARIS project manager.researcherFaculty of Life and Health Sciences, Ulster University, Coleraine, UKChildren’s Hospital Zagreb, Centre of Excellence for Reproductive and Regenerative Medicine, Medical School University of Zagreb, Zagreb, Croatiaregistry leaderIMER Registry (Emila Romagna Registry of Birth Defects), University Hospital of Ferrara, Emilia-Romagna, ItalyInstituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, ItalyMalformation Monitoring Centre Saxony-Anhalt, Otto von Guericke University Medical Faculty, Magdeburg, GermanyPopulation Health Research Institute, St George’s University of London, London, UKregistry leaderPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UKPaediatric Department, Hospital Lillebaelt, Kolding, DenmarklecturerDepartment of Genetics, University Medical Centre Groningen, Groningen, The NetherlandsPolish Registry of Congenital Malformations, Chair and Department of Medical Genetics, Poznan University of Medical Sciences, Poznan, PolandBiomedical Computing Limited, Battle, UKPopulation Health Research Institute, St George’s University of London, London, UKFaculty of Life and Health Sciences, Ulster University, Coleraine, UKPopulation Health Research Institute, St George’s University of London, London, UKIntroduction Congenital anomalies (CAs) are a major cause of infant mortality, childhood morbidity and long-term disability. Over 130 000 children born in Europe every year will have a CA. This paper describes the EUROlinkCAT study, which is investigating the health and educational outcomes of children with CAs for the first 10 years of their lives.Methods and analysis EUROCAT is a European network of population-based registries for the epidemiological surveillance of CAs. EUROlinkCAT is using the EUROCAT infrastructure to support 22 EUROCAT registries in 14 countries to link their data on births with CAs to mortality, hospital discharge, prescription and educational databases. Once linked, each registry transforms their case data into a common data model (CDM) format and they are then supplied with common STATA syntax scripts to analyse their data. The resulting aggregate tables and analysis results are submitted to a central results repository (CRR) and meta-analyses are performed to summarise the results across all registries. The CRR currently contains data on 155 594 children with a CA followed up to age 10 from a population of 6 million births from 1995 to 2014.Ethics The CA registries have the required ethics permissions for routine surveillance and transmission of anonymised data to the EUROCAT central database. Each registry is responsible for applying for and obtaining additional ethics and other permissions required for their participation in EUROlinkCAT.Dissemination The CDM and associated documentation, including linkage and standardisation procedures, will be available post-EUROlinkCAT thus facilitating future local, national and European-level analyses to improve healthcare. Recommendations to improve the accuracy of routinely collected data will be made.Findings will provide evidence to inform parents, health professionals, public health authorities and national treatment guidelines to optimise diagnosis, prevention and treatment for these children with a view to reducing health inequalities in Europe.https://bmjopen.bmj.com/content/11/6/e047859.full |