Interplay between the Gut Microbiota and Inflammatory Mediators in the Development of Colorectal Cancer

• Main Authors: Gwangbeom Heo, Yunna Lee, Eunok Im
• Format: Article
• Language: English
• Published: MDPI AG 2021-02-01
• Series: Cancers
• Subjects: microbiota; colorectal cancer; inflammatory mediators; fecal microbiota transplantation; germ-free animal
• Online Access: https://www.mdpi.com/2072-6694/13/4/734

Inflammatory mediators modulate inflammatory pathways during the development of colorectal cancer. Inflammatory mediators secreted by both immune and tumor cells can influence carcinogenesis, progression, and tumor metastasis. The gut microbiota, which colonize the entire intestinal tract, especially the colon, are closely linked to colorectal cancer through an association with inflammatory mediators such as tumor necrosis factor, nuclear factor kappa B, interleukins, and interferons. This association may be a potential therapeutic target, since therapeutic interventions targeting the gut microbiota have been actively investigated in both the laboratory and in clinics and include fecal microbiota transplantation and probiotics.