Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model

Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model

In our study, a chronic unpredictable mild stress-induced depression rat model was constructed then the antidepressant effects and mechanisms of Epigallocatechin-3-O-gallate (EGCG) have been evaluaed accordingly. In the study, there were three subgroups of stochastically-selected male Wistar rats, n...

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Main Authors: Jinpeng Wang, Shuang Xu, Xiaohui Chen, Long Wang, Jiayu Li, Guangjian Li, Beilin Zhang
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Journal of Functional Foods
Subjects:
EGCG
Hippocampus
Inflammatory
Apoptosis
Depression-related behavior
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620303303
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spelling doaj-71dea370831a42889586d16f260b7ff72021-04-30T07:19:26ZengElsevierJournal of Functional Foods1756-46462020-10-0173104106Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat modelJinpeng Wang0Shuang Xu1Xiaohui Chen2Long Wang3Jiayu Li4Guangjian Li5Beilin Zhang6Department of Cardiology, the Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Radiology, the First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Cardiology, the Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Cardiology, the Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Physiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China; Corresponding authors at: Department of Physiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin 130021, China (B. Zhang). Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China (G. Li).Department of Physiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China; Corresponding authors at: Department of Physiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin 130021, China (B. Zhang). Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China (G. Li).In our study, a chronic unpredictable mild stress-induced depression rat model was constructed then the antidepressant effects and mechanisms of Epigallocatechin-3-O-gallate (EGCG) have been evaluaed accordingly. In the study, there were three subgroups of stochastically-selected male Wistar rats, namely, Control, CUMS-induced (chronic unpredictable mild stress) and CUMS with EGCG administration. The outcomes of sucrose preference and open-field tests presented the antidepressant-like effects of EGCG. With EGCG treatment, the levels of IL-6 and NO had significantly declined. Through EGCG administration, the suppressed expression of caspase-3 and caspase-9 mRNA in hippocampus was exhibited in the experiment. The implication of experimental outcomes can be served as preclinical evidences for therapeutic applications in the treatment of depression potentially, because of the antidepressant-like role of EGCG played against inflammation to protect neurons in hippocampus.http://www.sciencedirect.com/science/article/pii/S1756464620303303EGCGHippocampusInflammatoryApoptosisDepression-related behavior
collection DOAJ
language English
format Article
sources DOAJ
author Jinpeng Wang
Shuang Xu
Xiaohui Chen
Long Wang
Jiayu Li
Guangjian Li
Beilin Zhang
spellingShingle Jinpeng Wang
Shuang Xu
Xiaohui Chen
Long Wang
Jiayu Li
Guangjian Li
Beilin Zhang
Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model
Journal of Functional Foods
EGCG
Hippocampus
Inflammatory
Apoptosis
Depression-related behavior
author_facet Jinpeng Wang
Shuang Xu
Xiaohui Chen
Long Wang
Jiayu Li
Guangjian Li
Beilin Zhang
author_sort Jinpeng Wang
title Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model
title_short Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model
title_full Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model
title_fullStr Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model
title_full_unstemmed Antidepressant effect of EGCG through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model
title_sort antidepressant effect of egcg through the inhibition of hippocampal neuroinflammation in chronic unpredictable mild stress-induced depression rat model
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2020-10-01
description In our study, a chronic unpredictable mild stress-induced depression rat model was constructed then the antidepressant effects and mechanisms of Epigallocatechin-3-O-gallate (EGCG) have been evaluaed accordingly. In the study, there were three subgroups of stochastically-selected male Wistar rats, namely, Control, CUMS-induced (chronic unpredictable mild stress) and CUMS with EGCG administration. The outcomes of sucrose preference and open-field tests presented the antidepressant-like effects of EGCG. With EGCG treatment, the levels of IL-6 and NO had significantly declined. Through EGCG administration, the suppressed expression of caspase-3 and caspase-9 mRNA in hippocampus was exhibited in the experiment. The implication of experimental outcomes can be served as preclinical evidences for therapeutic applications in the treatment of depression potentially, because of the antidepressant-like role of EGCG played against inflammation to protect neurons in hippocampus.
topic EGCG
Hippocampus
Inflammatory
Apoptosis
Depression-related behavior
url http://www.sciencedirect.com/science/article/pii/S1756464620303303
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AT shuangxu antidepressanteffectofegcgthroughtheinhibitionofhippocampalneuroinflammationinchronicunpredictablemildstressinduceddepressionratmodel
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