Influencing factors for the length of hospital stay in patients with drug-induced liver injury

• Main Authors: DU Shuixian, LU Linlin, XIN Yongning
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2016-07-01
• Series: Linchuang Gandanbing Zazhi
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=7546

ObjectiveTo investigate the influencing factors for the length of hospital stay in patients with drug-induced liver injury (DILI), and to guide clinical practice, reduce the pressure of hospitalization, and reduce the patients′ economic burden. MethodsThe clinical data of the patients with DILI who were hospitalized in Qingdao Municipal Hospital from January 2012 to December 2014 were collected, including age, sex, primary disease, medication history, routine blood test, liver function parameters, DILI type, medication, and prognosis. The Spearman rank correlation, Wilcoxon rank sum test, and Kruskal-Wallis H rank sum test were used to analyze the influencing factors for the length of hospital stay. A multivariate linear regression analysis was performed for the factors with statistical significance determined by the univariate analysis. ResultsThe clinical data of 191 patients with DILI were collected. Among these patients, there were 114 male and 77 female patients aged 11-84 years (mean 50.83±2.72 years), and the mean hospital stay was 14 days (range 4-41 days). Patient′s age, the highest levels of alanine aminotransferase (ALT)/alkaline phosphatase (ALP)/total bilirubin (TBil), and the lowest level of prothrombin activity (PTA) were positively correlated with the length of hospital stay (rs=0.388, 0.247, 0.172, 0.487, and 0.120, all P＜0.05). The presence or absence of the histories of underlying liver disease, hypertension, malignant tumors, tuberculosis, and hyperthyroidism, use of different suspected drugs, therapies for DILI, and DILI types were the influencing factors for the length of hospital stay in patients with DILI (all P＜0.05). The multivariate linear regression analysis showed that age, the histories of underlying liver disease and malignant tumors, traditional Chinese medicine, antipyretic and analgesic drugs, the highest levels of ALT/ALP/TBil, the lowest level of PTA, therapies for DILI, and DILI types were independent risk factors for the length of hospital stay in patients with DILI (all P＜0.05). ConclusionAge, the histories of underlying liver disease and malignant tumors, traditional Chinese medicine, antipyretic and analgesic drugs, the highest levels of ALT/ALP/TBil, the lowest level of PTA, therapies for DILI, and DILI types are influencing factors for the length of hospital stay in patients with DILI. Regulation of the influencing factors for the length of hospital stay during clinical diagnosis and treatment can reduce hospital costs and plays an important role in reducing healthcare burden.