Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor XIa

Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor XIa

The anticoagulant activity of lignosulfonic acid sodium (LSAS), a non-saccharide heparin mimetic, was investigated in this study. LSAS is a relatively safe industrial byproduct with similar polyanionic characteristics to that of heparin. Human plasma clotting assays, fibrin polymerization testing, a...

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Bibliographic Details
Main Authors:	Srabani Kar, Page Bankston, Daniel K. Afosah, Rami A. Al-Horani
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Pharmaceuticals
Subjects:	factor XIa allosteric inhibitor anticoagulant lignin sulfonate
Online Access:	https://www.mdpi.com/1424-8247/14/9/886

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