Effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: A retrospective study
Abstract Introduction: Hyperphosphatemia is a serious consequence of chronic kidney disease and has been associated with an increased risk for cardiovascular disease. Controlling serum phosphorus levels in patients on dialysis is a challenge for the clinicians and implies, in most cases, the use of...
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Sociedade Brasileira de Nefrologia
2019-02-01
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doaj-71fbc556c8ba4fea8c1a2aa3489e1d022020-11-24T23:08:17ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392019-02-01010.1590/2175-8239-jbn-2018-0142S0101-28002019005005101Effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: A retrospective studyAníbal FerreiraBruno PintoDavid NavarroJoão AnicetoPedro L NevesPedro PonceAbstract Introduction: Hyperphosphatemia is a serious consequence of chronic kidney disease and has been associated with an increased risk for cardiovascular disease. Controlling serum phosphorus levels in patients on dialysis is a challenge for the clinicians and implies, in most cases, the use of phosphate binders (PB). Part of the reason for this challenge is poor adherence to treatment because of the high pill burden in this patient group. Objective: To assess the real-world effectiveness of sucroferric oxyhydroxide (SO) in controlling serum phosphorus levels and determine the associated pill burden. Methods: A multicenter, quantitative, retrospective, before-after study was conducted with patients receiving online hemodiafiltration. Patients who switched to SO as a part of routine care were included in the study. PB treatment, number of pills, serum phosphorus levels, and intravenous iron medication and dosage were collected monthly during the six months of treatment with either PB or SO. Results: A total of 42 patients were included in the study. After switching from a PB to SO, the prescribed pills/day was reduced 67% from 6 pills/day to 2 pills/day (p < 0.001) and the frequency of pill intake was lowered from 3 times/day to 2 times/day (p < 0.001). During the treatment with SO, the proportion of patients with serum phosphorus ≤ 5.5 mg/dL increased from 33.3% at baseline to 45% after six months of treatment. Conclusion: During the six-month follow-up with SO, serum phosphorus levels were controlled with one third of the pills/day compared to other PB.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019005005101&lng=en&tlng=enSucroferric OxyhydroxideHyperphosphatemiaPhosphorusRenal Insufficiency, ChronicHemodiafiltration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aníbal Ferreira Bruno Pinto David Navarro João Aniceto Pedro L Neves Pedro Ponce |
spellingShingle |
Aníbal Ferreira Bruno Pinto David Navarro João Aniceto Pedro L Neves Pedro Ponce Effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: A retrospective study Brazilian Journal of Nephrology Sucroferric Oxyhydroxide Hyperphosphatemia Phosphorus Renal Insufficiency, Chronic Hemodiafiltration |
author_facet |
Aníbal Ferreira Bruno Pinto David Navarro João Aniceto Pedro L Neves Pedro Ponce |
author_sort |
Aníbal Ferreira |
title |
Effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: A retrospective study |
title_short |
Effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: A retrospective study |
title_full |
Effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: A retrospective study |
title_fullStr |
Effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: A retrospective study |
title_full_unstemmed |
Effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: A retrospective study |
title_sort |
effectiveness of sucroferric oxyhydroxide in patients on on-line hemodiafiltration in real-world clinical practice: a retrospective study |
publisher |
Sociedade Brasileira de Nefrologia |
series |
Brazilian Journal of Nephrology |
issn |
2175-8239 |
publishDate |
2019-02-01 |
description |
Abstract Introduction: Hyperphosphatemia is a serious consequence of chronic kidney disease and has been associated with an increased risk for cardiovascular disease. Controlling serum phosphorus levels in patients on dialysis is a challenge for the clinicians and implies, in most cases, the use of phosphate binders (PB). Part of the reason for this challenge is poor adherence to treatment because of the high pill burden in this patient group. Objective: To assess the real-world effectiveness of sucroferric oxyhydroxide (SO) in controlling serum phosphorus levels and determine the associated pill burden. Methods: A multicenter, quantitative, retrospective, before-after study was conducted with patients receiving online hemodiafiltration. Patients who switched to SO as a part of routine care were included in the study. PB treatment, number of pills, serum phosphorus levels, and intravenous iron medication and dosage were collected monthly during the six months of treatment with either PB or SO. Results: A total of 42 patients were included in the study. After switching from a PB to SO, the prescribed pills/day was reduced 67% from 6 pills/day to 2 pills/day (p < 0.001) and the frequency of pill intake was lowered from 3 times/day to 2 times/day (p < 0.001). During the treatment with SO, the proportion of patients with serum phosphorus ≤ 5.5 mg/dL increased from 33.3% at baseline to 45% after six months of treatment. Conclusion: During the six-month follow-up with SO, serum phosphorus levels were controlled with one third of the pills/day compared to other PB. |
topic |
Sucroferric Oxyhydroxide Hyperphosphatemia Phosphorus Renal Insufficiency, Chronic Hemodiafiltration |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019005005101&lng=en&tlng=en |
work_keys_str_mv |
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