Reduced susceptibility mechanism to cefiderocol, a siderophore cephalosporin, among clinical isolates from a global surveillance programme (SIDERO-WT-2014)

Reduced susceptibility mechanism to cefiderocol, a siderophore cephalosporin, among clinical isolates from a global surveillance programme (SIDERO-WT-2014)

Objective: To investigate possible mechanistic factors to explain cefiderocol (CFDC) non-susceptibility, we characterized 38 clinical isolates with a CFDC minimum inhibitory concentration (MIC) of >4 μg/mL from a multi-national surveillance study. Methods: The MIC measurement in the presence of β...

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Bibliographic Details
Main Authors: Naoki Kohira, Meredith A. Hackel, Yoshino Ishioka, Miho Kuroiwa, Daniel F. Sahm, Takafumi Sato, Hideki Maki, Yoshinori Yamano
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Cefiderocol
Siderophore cephalosporin
Gram-negative bacilli
PER-type β-lactamase
Cefiderocol non-susceptible
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716520301843

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