Specific Resting-state Brain Networks in Mesial Temporal Lobe Epilepsy
We studied with fMRI differences in resting-state networks between patients with mesial temporal lobe epilepsy (MTLE) and healthy subjects. To avoid any a priori hypothesis, we use a data-driven analysis assessing differences between groups independently of structures involved. Shared and specific i...
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doaj-7205603105c4437bbb97db8fcebee0ad2020-11-24T22:35:55ZengFrontiers Media S.A.Frontiers in Neurology1664-22952014-07-01510.3389/fneur.2014.0012788733Specific Resting-state Brain Networks in Mesial Temporal Lobe EpilepsyMona eManeshi0Shahabeddin eVahdat1Firas eFahoum2Christophe eGrova3Christophe eGrova4Jean eGotman5Montreal Neurological Institute and Hospital, McGill UniversityCentre de Recherche de l'Institut Universitaire de Gériatrie de MontréalMontreal Neurological Institute and Hospital, McGill UniversityMcGill UniversityMontreal Neurological Institute and Hospital, McGill UniversityMontreal Neurological Institute and Hospital, McGill UniversityWe studied with fMRI differences in resting-state networks between patients with mesial temporal lobe epilepsy (MTLE) and healthy subjects. To avoid any a priori hypothesis, we use a data-driven analysis assessing differences between groups independently of structures involved. Shared and specific independent component analysis (SSICA) is an exploratory method based on independent component analysis, which performs between-group network comparison. It extracts and classifies components (networks) in those common between groups and those specific to one group. Resting fMRI data was collected from 10 healthy subjects and 10 MTLE patients. SSICA was applied multiple times with altered initializations and different numbers of specific components. This resulted in many components specific to patients and to controls. Spatial clustering identified the reliable resting-state networks among all specific components in each group. For each reliable specific network, power spectrum analysis was performed on reconstructed time series to estimate connectivity in each group and differences between groups. Two reliable networks, corresponding to statistically significant clusters robustly detected with clustering were labelled as specific to MTLE and one as specific to the control group. The most reliable MTLE network included hippocampus and amygdala bilaterally. The other MTLE network included the postcentral gyri and temporal poles. The control-specific network included bilateral precuneus, anterior cingulate, thalamus, parahippocampal gyrus. Results indicated that the two MTLE networks show increased connectivity in patients whereas the control-specific network shows decreased connectivity in patients. Our findings complement results from seed-based connectivity analysis (Pittau et al., 2012). The pattern of changes in connectivity between mesial temporal lobe structures and other areas may help us understand the cognitive impairments often reported in patients with MTLE.http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00127/fullfunctional connectivityIndependent Component Analysisbrain networksTemporal Lobe EpilepsyResting-state fMRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mona eManeshi Shahabeddin eVahdat Firas eFahoum Christophe eGrova Christophe eGrova Jean eGotman |
spellingShingle |
Mona eManeshi Shahabeddin eVahdat Firas eFahoum Christophe eGrova Christophe eGrova Jean eGotman Specific Resting-state Brain Networks in Mesial Temporal Lobe Epilepsy Frontiers in Neurology functional connectivity Independent Component Analysis brain networks Temporal Lobe Epilepsy Resting-state fMRI |
author_facet |
Mona eManeshi Shahabeddin eVahdat Firas eFahoum Christophe eGrova Christophe eGrova Jean eGotman |
author_sort |
Mona eManeshi |
title |
Specific Resting-state Brain Networks in Mesial Temporal Lobe Epilepsy |
title_short |
Specific Resting-state Brain Networks in Mesial Temporal Lobe Epilepsy |
title_full |
Specific Resting-state Brain Networks in Mesial Temporal Lobe Epilepsy |
title_fullStr |
Specific Resting-state Brain Networks in Mesial Temporal Lobe Epilepsy |
title_full_unstemmed |
Specific Resting-state Brain Networks in Mesial Temporal Lobe Epilepsy |
title_sort |
specific resting-state brain networks in mesial temporal lobe epilepsy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2014-07-01 |
description |
We studied with fMRI differences in resting-state networks between patients with mesial temporal lobe epilepsy (MTLE) and healthy subjects. To avoid any a priori hypothesis, we use a data-driven analysis assessing differences between groups independently of structures involved. Shared and specific independent component analysis (SSICA) is an exploratory method based on independent component analysis, which performs between-group network comparison. It extracts and classifies components (networks) in those common between groups and those specific to one group. Resting fMRI data was collected from 10 healthy subjects and 10 MTLE patients. SSICA was applied multiple times with altered initializations and different numbers of specific components. This resulted in many components specific to patients and to controls. Spatial clustering identified the reliable resting-state networks among all specific components in each group. For each reliable specific network, power spectrum analysis was performed on reconstructed time series to estimate connectivity in each group and differences between groups. Two reliable networks, corresponding to statistically significant clusters robustly detected with clustering were labelled as specific to MTLE and one as specific to the control group. The most reliable MTLE network included hippocampus and amygdala bilaterally. The other MTLE network included the postcentral gyri and temporal poles. The control-specific network included bilateral precuneus, anterior cingulate, thalamus, parahippocampal gyrus. Results indicated that the two MTLE networks show increased connectivity in patients whereas the control-specific network shows decreased connectivity in patients. Our findings complement results from seed-based connectivity analysis (Pittau et al., 2012). The pattern of changes in connectivity between mesial temporal lobe structures and other areas may help us understand the cognitive impairments often reported in patients with MTLE. |
topic |
functional connectivity Independent Component Analysis brain networks Temporal Lobe Epilepsy Resting-state fMRI |
url |
http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00127/full |
work_keys_str_mv |
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