Expression and significance of HA/CD44 in glial cells and optic cross nerves
Hyaluronic acid(HA)is one of the main components of the extracellular matrix(ECM), and it is participated in many cells physiology and pathological processes, such as tissue reconstruction, expansion of cell gap, inflammation and tumorigenesis and so on. CD44 is a cell surface receptor for HA and wi...
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doaj-72070b1b9b694f218e0fbaa674957a232020-11-24T21:39:07ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232019-03-0119339840110.3980/j.issn.1672-5123.2019.3.11Expression and significance of HA/CD44 in glial cells and optic cross nervesMing-Shan Liu0Ya Mo1Pei Gu2Mu-Lin He3School of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, ChinaSchool of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, ChinaSchool of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, ChinaSchool of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, ChinaHyaluronic acid(HA)is one of the main components of the extracellular matrix(ECM), and it is participated in many cells physiology and pathological processes, such as tissue reconstruction, expansion of cell gap, inflammation and tumorigenesis and so on. CD44 is a cell surface receptor for HA and widely distributed cell surface glycoprotein, which paticipate in specific adhesion of cell to cell and cell to matrix. CD44 is the most important hyaluronic acid receptor on the cell surface. Besides, CD44 is the main site of binding to HA. In this paper, we will elaborate from three aspects: the binding of HA and CD44 and its molecular basis, the expression and significance of HA/CD44 in glial cells(including Müller cells)and the expression and significance of HA/CD44 in the optic nerve, which makes readers have an understanding of the role of HA and CD44.http://ies.ijo.cn/cn_publish/2019/3/201903011.pdfhyaluronic acidCD44Müller cellsglial cellsoptic nerves |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming-Shan Liu Ya Mo Pei Gu Mu-Lin He |
spellingShingle |
Ming-Shan Liu Ya Mo Pei Gu Mu-Lin He Expression and significance of HA/CD44 in glial cells and optic cross nerves Guoji Yanke Zazhi hyaluronic acid CD44 Müller cells glial cells optic nerves |
author_facet |
Ming-Shan Liu Ya Mo Pei Gu Mu-Lin He |
author_sort |
Ming-Shan Liu |
title |
Expression and significance of HA/CD44 in glial cells and optic cross nerves |
title_short |
Expression and significance of HA/CD44 in glial cells and optic cross nerves |
title_full |
Expression and significance of HA/CD44 in glial cells and optic cross nerves |
title_fullStr |
Expression and significance of HA/CD44 in glial cells and optic cross nerves |
title_full_unstemmed |
Expression and significance of HA/CD44 in glial cells and optic cross nerves |
title_sort |
expression and significance of ha/cd44 in glial cells and optic cross nerves |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
Guoji Yanke Zazhi |
issn |
1672-5123 1672-5123 |
publishDate |
2019-03-01 |
description |
Hyaluronic acid(HA)is one of the main components of the extracellular matrix(ECM), and it is participated in many cells physiology and pathological processes, such as tissue reconstruction, expansion of cell gap, inflammation and tumorigenesis and so on. CD44 is a cell surface receptor for HA and widely distributed cell surface glycoprotein, which paticipate in specific adhesion of cell to cell and cell to matrix. CD44 is the most important hyaluronic acid receptor on the cell surface. Besides, CD44 is the main site of binding to HA. In this paper, we will elaborate from three aspects: the binding of HA and CD44 and its molecular basis, the expression and significance of HA/CD44 in glial cells(including Müller cells)and the expression and significance of HA/CD44 in the optic nerve, which makes readers have an understanding of the role of HA and CD44. |
topic |
hyaluronic acid CD44 Müller cells glial cells optic nerves |
url |
http://ies.ijo.cn/cn_publish/2019/3/201903011.pdf |
work_keys_str_mv |
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1725932560710631424 |