Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives

Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives

New sugar hydrazone moieties, their oxadiazoline derivatives, and arylidene analogues were prepared and chemically elucidated using spectroscopic analysis, such as nuclear magnetic resonance, for hydrogen 1HNMR, carbon 13CNMR, elemental analysis, and Infrared (IR). The prepared compounds were purifi...

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Main Author: Saad H. Alotabi
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Arabian Journal of Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535219301807
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spelling doaj-72095d0e9b9d4dbcbf9e4804cd37f59f2020-11-25T02:13:24ZengElsevierArabian Journal of Chemistry1878-53522020-03-0113347714784Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivativesSaad H. Alotabi0Address: Department of Chemistry, Turabah University College, Taif University, Box No 311, 21995, Saudi Arabia.; Department of Chemistry, Turabah University College, Taif University, Turabah, Taif, Saudi ArabiaNew sugar hydrazone moieties, their oxadiazoline derivatives, and arylidene analogues were prepared and chemically elucidated using spectroscopic analysis, such as nuclear magnetic resonance, for hydrogen 1HNMR, carbon 13CNMR, elemental analysis, and Infrared (IR). The prepared compounds were purified and tested against breast cancer cells (MCF-7). Compounds 4c, 4d, 6b, and 6d exhibited moderate to very high anti-breast cancer activity, with a percentage of inhibition of 96.19%, 93.08%, 74.33%, and 86.05% respectively; the reference 5-fluorouracil had an inhibitory percentage of 96.02%. Keywords: Sugar hydrazones, Arylidene derivatives, Oxadiazolines, Molecular docking, Antimicrobial activityhttp://www.sciencedirect.com/science/article/pii/S1878535219301807
collection DOAJ
language English
format Article
sources DOAJ
author Saad H. Alotabi
spellingShingle Saad H. Alotabi
Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives
Arabian Journal of Chemistry
author_facet Saad H. Alotabi
author_sort Saad H. Alotabi
title Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives
title_short Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives
title_full Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives
title_fullStr Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives
title_full_unstemmed Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives
title_sort synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives
publisher Elsevier
series Arabian Journal of Chemistry
issn 1878-5352
publishDate 2020-03-01
description New sugar hydrazone moieties, their oxadiazoline derivatives, and arylidene analogues were prepared and chemically elucidated using spectroscopic analysis, such as nuclear magnetic resonance, for hydrogen 1HNMR, carbon 13CNMR, elemental analysis, and Infrared (IR). The prepared compounds were purified and tested against breast cancer cells (MCF-7). Compounds 4c, 4d, 6b, and 6d exhibited moderate to very high anti-breast cancer activity, with a percentage of inhibition of 96.19%, 93.08%, 74.33%, and 86.05% respectively; the reference 5-fluorouracil had an inhibitory percentage of 96.02%. Keywords: Sugar hydrazones, Arylidene derivatives, Oxadiazolines, Molecular docking, Antimicrobial activity
url http://www.sciencedirect.com/science/article/pii/S1878535219301807
work_keys_str_mv AT saadhalotabi synthesischaracterizationanticanceractivityandmoleculardockingofsomenewsugarhydrazoneandarylidenederivatives
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