Imaging and clinical features of Castleman Disease
Abstract Background Castleman disease (CD) is a group of uncommon lymphoproliferative disorders that is easily confused with lymphoma or other solid tumors. The purpose of our study was to evaluate the imaging and clinical findings of CD, and thus improve the understanding and diagnosis of CD. Metho...
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doaj-720d28aa6817474cb2007457523eb0c52021-04-02T12:17:08ZengBMCCancer Imaging1470-73302019-07-011911810.1186/s40644-019-0238-0Imaging and clinical features of Castleman DiseaseShuang Zhao0Ying Wan1Zixing Huang2Bin Song3Jianqun Yu4Department of Radiology, West China Hospital, Sichuan UniversityDepartment of Pathology, West China Hospital of Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityAbstract Background Castleman disease (CD) is a group of uncommon lymphoproliferative disorders that is easily confused with lymphoma or other solid tumors. The purpose of our study was to evaluate the imaging and clinical findings of CD, and thus improve the understanding and diagnosis of CD. Methods This retrospective study included 74 patients (37 men and 37 women, mean age ± standard deviation, 35 ± 15.2 years,) with histopathologically confirmed CD diagnosed based on CT or MRI between January 2010 and May 2017. The CT and MRI findings were analyzed by two radiologists in consensus, and clinical presentation and histopathologic characteristics were documented. Results The CD subtypes included 61 hyaline vascular variant cases (82.4%) and 13 plasma cell variant cases (17.6%). Unicentric CD and multicentric CD were observed in 65 (87.8%) and 9 (12.2%) patients, respectively. On non-enhanced CT, enlarged nodes with hypodensity or isodensity were seen, whereas varying degrees of enhancement were observed in contrast-enhanced CT. Homogeneous and heterogeneous enhancements were observed in 43 (62.3%) and 26 (37.7%) patients, respectively. Hypertrophied vessels and calcification were detected in 38 (51.2%) and 18 (24.3%) patients, respectively. MRI revealed hypointense to isointense lesions on T1-weighted images, isointense to hyperintense lesions on T2-weighted images, and hyperintense lesions on diffusion-weighted imaging; 9 (75%) and 3 (25%) patients demonstrated homogeneous and heterogeneous enhancement, respectively. Conclusion CD often shows well-defined, mildly hypodense or isodense, homogeneous lymph nodules on non-enhanced CT/MRI, with intermediate and marked enhancement on contrast-enhanced CT/MRI. Calcification and hypertrophied vessels may be valuable diagnostic features.http://link.springer.com/article/10.1186/s40644-019-0238-0Castleman diseaseComputed tomographyMagnetic resonance imagingDiffusion-weighted imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuang Zhao Ying Wan Zixing Huang Bin Song Jianqun Yu |
spellingShingle |
Shuang Zhao Ying Wan Zixing Huang Bin Song Jianqun Yu Imaging and clinical features of Castleman Disease Cancer Imaging Castleman disease Computed tomography Magnetic resonance imaging Diffusion-weighted imaging |
author_facet |
Shuang Zhao Ying Wan Zixing Huang Bin Song Jianqun Yu |
author_sort |
Shuang Zhao |
title |
Imaging and clinical features of Castleman Disease |
title_short |
Imaging and clinical features of Castleman Disease |
title_full |
Imaging and clinical features of Castleman Disease |
title_fullStr |
Imaging and clinical features of Castleman Disease |
title_full_unstemmed |
Imaging and clinical features of Castleman Disease |
title_sort |
imaging and clinical features of castleman disease |
publisher |
BMC |
series |
Cancer Imaging |
issn |
1470-7330 |
publishDate |
2019-07-01 |
description |
Abstract Background Castleman disease (CD) is a group of uncommon lymphoproliferative disorders that is easily confused with lymphoma or other solid tumors. The purpose of our study was to evaluate the imaging and clinical findings of CD, and thus improve the understanding and diagnosis of CD. Methods This retrospective study included 74 patients (37 men and 37 women, mean age ± standard deviation, 35 ± 15.2 years,) with histopathologically confirmed CD diagnosed based on CT or MRI between January 2010 and May 2017. The CT and MRI findings were analyzed by two radiologists in consensus, and clinical presentation and histopathologic characteristics were documented. Results The CD subtypes included 61 hyaline vascular variant cases (82.4%) and 13 plasma cell variant cases (17.6%). Unicentric CD and multicentric CD were observed in 65 (87.8%) and 9 (12.2%) patients, respectively. On non-enhanced CT, enlarged nodes with hypodensity or isodensity were seen, whereas varying degrees of enhancement were observed in contrast-enhanced CT. Homogeneous and heterogeneous enhancements were observed in 43 (62.3%) and 26 (37.7%) patients, respectively. Hypertrophied vessels and calcification were detected in 38 (51.2%) and 18 (24.3%) patients, respectively. MRI revealed hypointense to isointense lesions on T1-weighted images, isointense to hyperintense lesions on T2-weighted images, and hyperintense lesions on diffusion-weighted imaging; 9 (75%) and 3 (25%) patients demonstrated homogeneous and heterogeneous enhancement, respectively. Conclusion CD often shows well-defined, mildly hypodense or isodense, homogeneous lymph nodules on non-enhanced CT/MRI, with intermediate and marked enhancement on contrast-enhanced CT/MRI. Calcification and hypertrophied vessels may be valuable diagnostic features. |
topic |
Castleman disease Computed tomography Magnetic resonance imaging Diffusion-weighted imaging |
url |
http://link.springer.com/article/10.1186/s40644-019-0238-0 |
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