Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population
Abstract Introduction The 5‐HTR2A gene has been implicated as candidate gene for eating disorders. The aim of the present study was to analyze the association of rs6311 and rs6313 polymorphisms of 5‐HTR2A gene with eating disorders in Mexican population, and to evaluate if the polymorphisms of 5‐HTR...
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doaj-721269a582754186a0aa003acc4f675e2020-11-25T02:38:58ZengWileyBrain and Behavior2162-32792019-07-0197n/an/a10.1002/brb3.1286Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican populationAlma Delia Genis‐Mendoza0David Ruiz‐Ramos1María Lilia López‐Narvaez2Carlos Alfonso Tovilla‐Zárate3Ana Rosa García4Gabriela Cortes Meda5José Jaime Martinez‐Magaña6Thelma Beatriz González‐Castro7Isela Esther Juárez‐Rojop8Humberto Nicolini9Instituto Nacional de Medicina Genómica (INMEGEN) Ciudad de México MéxicoDivisión Académica de Ciencias de la Salud Universidad Juárez Autónoma de Tabasco Villahermosa Tabasco MéxicoHospital General de Yajalón “Manuel Velazco Suarez” Secretaría de Salud Yajalón Chiapas MéxicoDivisión Académica Multidisciplinaria de Comalcalco Universidad Juárez Autónoma de Tabasco Comalcalco Tabasco MéxicoHospital Psiquiátrico Infantil Juan N Navarro Secretaría de Salud Ciudad de México MéxicoHospital Psiquiátrico Infantil Juan N Navarro Secretaría de Salud Ciudad de México MéxicoInstituto Nacional de Medicina Genómica (INMEGEN) Ciudad de México MéxicoDivisión Académica Multidisciplinaria de Jalpa de Méndez Universidad Juárez Autónoma de Tabasco Jalpa de Méndez Tabasco MéxicoDivisión Académica Multidisciplinaria de Jalpa de Méndez Universidad Juárez Autónoma de Tabasco Jalpa de Méndez Tabasco MéxicoInstituto Nacional de Medicina Genómica (INMEGEN) Ciudad de México MéxicoAbstract Introduction The 5‐HTR2A gene has been implicated as candidate gene for eating disorders. The aim of the present study was to analyze the association of rs6311 and rs6313 polymorphisms of 5‐HTR2A gene with eating disorders in Mexican population, and to evaluate if the polymorphisms of 5‐HTR2A gene were associated with comorbidities in eating behavior. Methods We conducted a case–control analysis with 460 subjects. We included 168 patients with eating disorders and 292 controls; two polymorphisms of 5‐HTR2A gene were genotyped. We assessed the association by allele, genotype, and inheritance models. Psychiatric comorbidities were analyzed by genotype in patients with eating disorders. Results We found an association between rs6311 and eating disorders in a Mexican population by allele (OR = 8.09; 95% CI = 5.99–11.03; p = 2.2e‐16) and genotype (OR = 76.14; 95% CI = 35.61–177.18; p = 2.2e‐16). Individuals who carried GG genotype showed increased risk for suicide attempted (OR = 2.14; CI = 1.10–4.26; p = 0.035) as comorbidity associated with eating disorders. No positive associations were observed for rs6313 polymorphism. Conclusion Our results showed an association of rs6311 (A1438G) polymorphism of 5‐HTR2A gene with eating disorders, and these polymorphic variants could increase the risk of psychiatric comorbidities. However, more studies are required to replicate the results and to reach to a conclusive association between eating disorders and rs6311.https://doi.org/10.1002/brb3.12865HTR2A geneGeneMexican populationSerotonin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alma Delia Genis‐Mendoza David Ruiz‐Ramos María Lilia López‐Narvaez Carlos Alfonso Tovilla‐Zárate Ana Rosa García Gabriela Cortes Meda José Jaime Martinez‐Magaña Thelma Beatriz González‐Castro Isela Esther Juárez‐Rojop Humberto Nicolini |
spellingShingle |
Alma Delia Genis‐Mendoza David Ruiz‐Ramos María Lilia López‐Narvaez Carlos Alfonso Tovilla‐Zárate Ana Rosa García Gabriela Cortes Meda José Jaime Martinez‐Magaña Thelma Beatriz González‐Castro Isela Esther Juárez‐Rojop Humberto Nicolini Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population Brain and Behavior 5HTR2A gene Gene Mexican population Serotonin |
author_facet |
Alma Delia Genis‐Mendoza David Ruiz‐Ramos María Lilia López‐Narvaez Carlos Alfonso Tovilla‐Zárate Ana Rosa García Gabriela Cortes Meda José Jaime Martinez‐Magaña Thelma Beatriz González‐Castro Isela Esther Juárez‐Rojop Humberto Nicolini |
author_sort |
Alma Delia Genis‐Mendoza |
title |
Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population |
title_short |
Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population |
title_full |
Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population |
title_fullStr |
Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population |
title_full_unstemmed |
Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population |
title_sort |
genetic association analysis of 5‐htr2a gene variants in eating disorders in a mexican population |
publisher |
Wiley |
series |
Brain and Behavior |
issn |
2162-3279 |
publishDate |
2019-07-01 |
description |
Abstract Introduction The 5‐HTR2A gene has been implicated as candidate gene for eating disorders. The aim of the present study was to analyze the association of rs6311 and rs6313 polymorphisms of 5‐HTR2A gene with eating disorders in Mexican population, and to evaluate if the polymorphisms of 5‐HTR2A gene were associated with comorbidities in eating behavior. Methods We conducted a case–control analysis with 460 subjects. We included 168 patients with eating disorders and 292 controls; two polymorphisms of 5‐HTR2A gene were genotyped. We assessed the association by allele, genotype, and inheritance models. Psychiatric comorbidities were analyzed by genotype in patients with eating disorders. Results We found an association between rs6311 and eating disorders in a Mexican population by allele (OR = 8.09; 95% CI = 5.99–11.03; p = 2.2e‐16) and genotype (OR = 76.14; 95% CI = 35.61–177.18; p = 2.2e‐16). Individuals who carried GG genotype showed increased risk for suicide attempted (OR = 2.14; CI = 1.10–4.26; p = 0.035) as comorbidity associated with eating disorders. No positive associations were observed for rs6313 polymorphism. Conclusion Our results showed an association of rs6311 (A1438G) polymorphism of 5‐HTR2A gene with eating disorders, and these polymorphic variants could increase the risk of psychiatric comorbidities. However, more studies are required to replicate the results and to reach to a conclusive association between eating disorders and rs6311. |
topic |
5HTR2A gene Gene Mexican population Serotonin |
url |
https://doi.org/10.1002/brb3.1286 |
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