The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands

The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands

Although primary Sjögren’s syndrome (pSS) is a mild indolent chronic disease mainly characterized by mucosal dryness in the majority of cases, a consistent subgroup of patients display extra-glandular manifestations. Virtually any organs and systems can be affected, leading to a more serious disease...

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Main Authors: M.C. Leone, A. Alunno, G. Cafaro, V. Valentini, E. Marcucci, E. Bartoloni, R. Gerli
Format: Article
Language:English
Published: PAGEPress Publications 2017-09-01
Series:Reumatismo
Subjects:
Sjögren’s syndrome
Extra-glandular manifestations
Cardiovascular risk.
Online Access:http://www.reumatismo.org/index.php/reuma/article/view/1032
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spelling doaj-722c70e9f8964577a2572ce3fb7cb1d32020-11-24T20:45:53ZengPAGEPress PublicationsReumatismo0048-74492240-26832017-09-016939310010.4081/reumatismo.2017.1032747The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glandsM.C. Leone0A. Alunno1G. Cafaro2V. Valentini3E. Marcucci4E. Bartoloni5R. Gerli6Rheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaAlthough primary Sjögren’s syndrome (pSS) is a mild indolent chronic disease mainly characterized by mucosal dryness in the majority of cases, a consistent subgroup of patients display extra-glandular manifestations. Virtually any organs and systems can be affected, leading to a more serious disease prognosis. Therefore, the prompt identification of patients at higher risk of extra-glandular manifestations is necessary to start a thorough follow up and an aggressive treatment. The aim of this review article is to provide an overview of epidemiological, clinical and serological features of extra-glandular manifestations in pSS as well as current knowledge about putative biomarkers useful in clinical practice.http://www.reumatismo.org/index.php/reuma/article/view/1032Sjögren’s syndromeExtra-glandular manifestationsCardiovascular risk.
collection DOAJ
language English
format Article
sources DOAJ
author M.C. Leone
A. Alunno
G. Cafaro
V. Valentini
E. Marcucci
E. Bartoloni
R. Gerli
spellingShingle M.C. Leone
A. Alunno
G. Cafaro
V. Valentini
E. Marcucci
E. Bartoloni
R. Gerli
The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands
Reumatismo
Sjögren’s syndrome
Extra-glandular manifestations
Cardiovascular risk.
author_facet M.C. Leone
A. Alunno
G. Cafaro
V. Valentini
E. Marcucci
E. Bartoloni
R. Gerli
author_sort M.C. Leone
title The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands
title_short The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands
title_full The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands
title_fullStr The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands
title_full_unstemmed The clinical spectrum of primary Sjögren’s syndrome: beyond exocrine glands
title_sort clinical spectrum of primary sjögren’s syndrome: beyond exocrine glands
publisher PAGEPress Publications
series Reumatismo
issn 0048-7449
2240-2683
publishDate 2017-09-01
description Although primary Sjögren’s syndrome (pSS) is a mild indolent chronic disease mainly characterized by mucosal dryness in the majority of cases, a consistent subgroup of patients display extra-glandular manifestations. Virtually any organs and systems can be affected, leading to a more serious disease prognosis. Therefore, the prompt identification of patients at higher risk of extra-glandular manifestations is necessary to start a thorough follow up and an aggressive treatment. The aim of this review article is to provide an overview of epidemiological, clinical and serological features of extra-glandular manifestations in pSS as well as current knowledge about putative biomarkers useful in clinical practice.
topic Sjögren’s syndrome
Extra-glandular manifestations
Cardiovascular risk.
url http://www.reumatismo.org/index.php/reuma/article/view/1032
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