Homers at the interface between reward and pain

Homers at the interface between reward and pain

Pain alters opioid reinforcement, via neuroadaptations within ascending pain pathways interacting with the limbic system. Nerve injury increases expression of glutamate receptors and Homer scaffolding proteins throughout the pain processing pathway and these molecules regulate behavioral sensitivity...

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Bibliographic Details
Main Authors: Ilona eObara, Scott eGoulding, Adam eGould, Kevin eLominac, Jia-Hua eHu, Ping Wu eZhang, Georg evon Jonquieres, Marlin eDehoff, Bo eXiao, Peter H Seeburg, Paul eWorley, Matthias eKlugmann, Karen K Szumlinski
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Psychiatry
Subjects:
Heroin
Nucleus Accumbens
neuropathic pain
NMDA receptors
Homer proteins
Group1 metabotropic glutamate receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00039/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00039/full

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