Epigenetic signature of preterm birth in adult twins
Abstract Background Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors, and these could be persistent and detrimental to health later in life. Methods We performed a genome-wide DNA methyla...
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doaj-72366f8b172042c1a0c030a5ad02948c2020-11-25T00:35:06ZengBMCClinical Epigenetics1868-70751868-70832018-06-0110111010.1186/s13148-018-0518-8Epigenetic signature of preterm birth in adult twinsQihua Tan0Shuxia Li1Morten Frost2Marianne Nygaard3Mette Soerensen4Martin Larsen5Kaare Christensen6Lene Christiansen7Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern DenmarkUnit of Human Genetics, Department of Clinical Research, University of Southern DenmarkDepartment of Endocrinology, Odense University HospitalEpidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern DenmarkEpidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern DenmarkUnit of Human Genetics, Department of Clinical Research, University of Southern DenmarkEpidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern DenmarkEpidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern DenmarkAbstract Background Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors, and these could be persistent and detrimental to health later in life. Methods We performed a genome-wide DNA methylation profiling in adult twins of premature birth to identify genomic regions under differential epigenetic regulation in 144 twins with a median age of 33 years (age range 30–36). Results Association analysis detected three genomic regions annotated to the SDHAP3, TAGLN3 and GSTT1 genes on chromosomes 5, 3 and 22 (FWER: 0.01, 0.02 and 0.04) respectively. These genes display strong involvement in neurodevelopmental disorders, cancer susceptibility and premature delivery. The three identified significant regions were successfully replicated in an independent sample of twins of even older age (median age 66, range 56–80) with similar regulatory patterns and nominal p values < 5.05e−04. Biological pathway analysis detected five significantly enriched pathways all explicitly involved in immune responses. Conclusion We have found novel evidence associating premature delivery with epigenetic modification of important genes/pathways and revealed that preterm birth, as an early life event, could be related to differential methylation regulation patterns observable in adults and even at high ages which could potentially mediate susceptibility to age-related diseases and adult health.http://link.springer.com/article/10.1186/s13148-018-0518-8Preterm birthTwinsEpigeneticsEpigenome-wide association studyAdults |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qihua Tan Shuxia Li Morten Frost Marianne Nygaard Mette Soerensen Martin Larsen Kaare Christensen Lene Christiansen |
spellingShingle |
Qihua Tan Shuxia Li Morten Frost Marianne Nygaard Mette Soerensen Martin Larsen Kaare Christensen Lene Christiansen Epigenetic signature of preterm birth in adult twins Clinical Epigenetics Preterm birth Twins Epigenetics Epigenome-wide association study Adults |
author_facet |
Qihua Tan Shuxia Li Morten Frost Marianne Nygaard Mette Soerensen Martin Larsen Kaare Christensen Lene Christiansen |
author_sort |
Qihua Tan |
title |
Epigenetic signature of preterm birth in adult twins |
title_short |
Epigenetic signature of preterm birth in adult twins |
title_full |
Epigenetic signature of preterm birth in adult twins |
title_fullStr |
Epigenetic signature of preterm birth in adult twins |
title_full_unstemmed |
Epigenetic signature of preterm birth in adult twins |
title_sort |
epigenetic signature of preterm birth in adult twins |
publisher |
BMC |
series |
Clinical Epigenetics |
issn |
1868-7075 1868-7083 |
publishDate |
2018-06-01 |
description |
Abstract Background Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors, and these could be persistent and detrimental to health later in life. Methods We performed a genome-wide DNA methylation profiling in adult twins of premature birth to identify genomic regions under differential epigenetic regulation in 144 twins with a median age of 33 years (age range 30–36). Results Association analysis detected three genomic regions annotated to the SDHAP3, TAGLN3 and GSTT1 genes on chromosomes 5, 3 and 22 (FWER: 0.01, 0.02 and 0.04) respectively. These genes display strong involvement in neurodevelopmental disorders, cancer susceptibility and premature delivery. The three identified significant regions were successfully replicated in an independent sample of twins of even older age (median age 66, range 56–80) with similar regulatory patterns and nominal p values < 5.05e−04. Biological pathway analysis detected five significantly enriched pathways all explicitly involved in immune responses. Conclusion We have found novel evidence associating premature delivery with epigenetic modification of important genes/pathways and revealed that preterm birth, as an early life event, could be related to differential methylation regulation patterns observable in adults and even at high ages which could potentially mediate susceptibility to age-related diseases and adult health. |
topic |
Preterm birth Twins Epigenetics Epigenome-wide association study Adults |
url |
http://link.springer.com/article/10.1186/s13148-018-0518-8 |
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