FBXO2 Promotes Proliferation of Endometrial Cancer by Ubiquitin-Mediated Degradation of FBN1 in the Regulation of the Cell Cycle and the Autophagy Pathway

FBXO2 Promotes Proliferation of Endometrial Cancer by Ubiquitin-Mediated Degradation of FBN1 in the Regulation of the Cell Cycle and the Autophagy Pathway

F-box proteins, as substrates for S phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes, mediate the degradation of a large number of regulatory proteins involved in cancer processes. In this study, we found that F-box only protein 2 (FBXO2) was up...

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Bibliographic Details
Main Authors: Xiaoxia Che, Fangfang Jian, Ying Wang, Jingjing Zhang, Jian Shen, Qi Cheng, Xi Wang, Nan Jia, Weiwei Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
endometrial carcinoma
FBXO2
FBN1
ubiquitination
cell cycle
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00843/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00843/full

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