Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation

Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation

We aimed to develop a berberine formulation to enhance the intestinal absorption and plasma concentrations of berberine through the inhibition of P-glycoprotein (P-gp)-mediated efflux and the intestinal metabolism of berberine in rats. We used pluronic P85 (P85) and tween 80, which have the potentia...

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Bibliographic Details
Main Authors: Mihwa Kwon, Dong Yu Lim, Chul Haeng Lee, Ji-Hyeon Jeon, Min-Koo Choi, Im-Sook Song
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
berberine
pluronic P85 (P85)
tween 80
pharmacokinetics
P-gp inhibition
CYP inhibition
Online Access:https://www.mdpi.com/1999-4923/12/9/882

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