<it>Multidrug resistance-associated protein-1 (MRP1) </it>genetic variants, MRP1 protein levels and severity of COPD
<p>Abstract</p> <p>Background</p> <p>Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (COPD). We have previously...
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doaj-7250196176af42bab266d6e6b2d1b02d2020-11-24T20:48:13ZengBMCRespiratory Research1465-99212010-05-011116010.1186/1465-9921-11-60<it>Multidrug resistance-associated protein-1 (MRP1) </it>genetic variants, MRP1 protein levels and severity of COPDRutgers BeaVonk Judith MSmit Henriette ASiedlinski MateuszKunz Lisette IZHiemstra Pieter SPostma Dirkje SBudulac Simona ETimens WimBoezen H Marike<p>Abstract</p> <p>Background</p> <p>Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (COPD). We have previously shown that single nucleotide polymorphisms (SNPs) in <it>MRP1 </it>significantly associate with level of FEV<sub>1 </sub>in two independent population based cohorts. The aim of our study was to assess the associations of <it>MRP1 </it>SNPs with FEV<sub>1 </sub>level, MRP1 protein levels and inflammatory markers in bronchial biopsies and sputum of COPD patients.</p> <p>Methods</p> <p>Five SNPs (rs212093, rs4148382, rs504348, rs4781699, rs35621) in <it>MRP1 </it>were genotyped in 110 COPD patients. The effects of <it>MRP1 </it>SNPs were analyzed using linear regression models.</p> <p>Results</p> <p>One SNP, rs212093 was significantly associated with a higher FEV<sub>1 </sub>level and less airway wall inflammation. Another SNP, rs4148382 was significantly associated with a lower FEV<sub>1 </sub>level, higher number of inflammatory cells in induced sputum and with a higher MRP1 protein level in bronchial biopsies.</p> <p>Conclusions</p> <p>This is the first study linking <it>MRP1 </it>SNPs with lung function and inflammatory markers in COPD patients, suggesting a role of <it>MRP1 </it>SNPs in the severity of COPD in addition to their association with MRP1 protein level in bronchial biopsies.</p> http://respiratory-research.com/content/11/1/60 |
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language |
English |
format |
Article |
sources |
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author |
Rutgers Bea Vonk Judith M Smit Henriette A Siedlinski Mateusz Kunz Lisette IZ Hiemstra Pieter S Postma Dirkje S Budulac Simona E Timens Wim Boezen H Marike |
spellingShingle |
Rutgers Bea Vonk Judith M Smit Henriette A Siedlinski Mateusz Kunz Lisette IZ Hiemstra Pieter S Postma Dirkje S Budulac Simona E Timens Wim Boezen H Marike <it>Multidrug resistance-associated protein-1 (MRP1) </it>genetic variants, MRP1 protein levels and severity of COPD Respiratory Research |
author_facet |
Rutgers Bea Vonk Judith M Smit Henriette A Siedlinski Mateusz Kunz Lisette IZ Hiemstra Pieter S Postma Dirkje S Budulac Simona E Timens Wim Boezen H Marike |
author_sort |
Rutgers Bea |
title |
<it>Multidrug resistance-associated protein-1 (MRP1) </it>genetic variants, MRP1 protein levels and severity of COPD |
title_short |
<it>Multidrug resistance-associated protein-1 (MRP1) </it>genetic variants, MRP1 protein levels and severity of COPD |
title_full |
<it>Multidrug resistance-associated protein-1 (MRP1) </it>genetic variants, MRP1 protein levels and severity of COPD |
title_fullStr |
<it>Multidrug resistance-associated protein-1 (MRP1) </it>genetic variants, MRP1 protein levels and severity of COPD |
title_full_unstemmed |
<it>Multidrug resistance-associated protein-1 (MRP1) </it>genetic variants, MRP1 protein levels and severity of COPD |
title_sort |
<it>multidrug resistance-associated protein-1 (mrp1) </it>genetic variants, mrp1 protein levels and severity of copd |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-9921 |
publishDate |
2010-05-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (COPD). We have previously shown that single nucleotide polymorphisms (SNPs) in <it>MRP1 </it>significantly associate with level of FEV<sub>1 </sub>in two independent population based cohorts. The aim of our study was to assess the associations of <it>MRP1 </it>SNPs with FEV<sub>1 </sub>level, MRP1 protein levels and inflammatory markers in bronchial biopsies and sputum of COPD patients.</p> <p>Methods</p> <p>Five SNPs (rs212093, rs4148382, rs504348, rs4781699, rs35621) in <it>MRP1 </it>were genotyped in 110 COPD patients. The effects of <it>MRP1 </it>SNPs were analyzed using linear regression models.</p> <p>Results</p> <p>One SNP, rs212093 was significantly associated with a higher FEV<sub>1 </sub>level and less airway wall inflammation. Another SNP, rs4148382 was significantly associated with a lower FEV<sub>1 </sub>level, higher number of inflammatory cells in induced sputum and with a higher MRP1 protein level in bronchial biopsies.</p> <p>Conclusions</p> <p>This is the first study linking <it>MRP1 </it>SNPs with lung function and inflammatory markers in COPD patients, suggesting a role of <it>MRP1 </it>SNPs in the severity of COPD in addition to their association with MRP1 protein level in bronchial biopsies.</p> |
url |
http://respiratory-research.com/content/11/1/60 |
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