microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression

microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression

Functional miRNAs derived from the 5p or 3p arm of some miRNA duplexes have opposite roles in cancer progression. Here, the authors show that oncogenic miR-574-5p has greater preference in aggressive gastric cancer as compared with miR-574-3p and this arm preference is partly dependent on complement...

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Main Authors: Zhengyi Zhang, Jingnan Pi, Dongling Zou, Xiaoshuang Wang, Jiayue Xu, Shan Yu, Ting Zhang, Feng Li, Xianxie Zhang, Hualu Zhao, Fang Wang, Dong Wang, Yanni Ma, Jia Yu
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12292-5
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spelling doaj-7260606bc40d4b239a3f39b04abc4d572021-05-11T11:35:40ZengNature Publishing GroupNature Communications2041-17232019-09-0110111610.1038/s41467-019-12292-5microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progressionZhengyi Zhang0Jingnan Pi1Dongling Zou2Xiaoshuang Wang3Jiayue Xu4Shan Yu5Ting Zhang6Feng Li7Xianxie Zhang8Hualu Zhao9Fang Wang10Dong Wang11Yanni Ma12Jia Yu13State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer HospitalState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical UniversityMolecular Biology Laboratory, Shanxi Cancer HospitalState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical UniversityState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)Functional miRNAs derived from the 5p or 3p arm of some miRNA duplexes have opposite roles in cancer progression. Here, the authors show that oncogenic miR-574-5p has greater preference in aggressive gastric cancer as compared with miR-574-3p and this arm preference is partly dependent on complementary targets mediated miRNA decay.https://doi.org/10.1038/s41467-019-12292-5
collection DOAJ
language English
format Article
sources DOAJ
author Zhengyi Zhang
Jingnan Pi
Dongling Zou
Xiaoshuang Wang
Jiayue Xu
Shan Yu
Ting Zhang
Feng Li
Xianxie Zhang
Hualu Zhao
Fang Wang
Dong Wang
Yanni Ma
Jia Yu
spellingShingle Zhengyi Zhang
Jingnan Pi
Dongling Zou
Xiaoshuang Wang
Jiayue Xu
Shan Yu
Ting Zhang
Feng Li
Xianxie Zhang
Hualu Zhao
Fang Wang
Dong Wang
Yanni Ma
Jia Yu
microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
Nature Communications
author_facet Zhengyi Zhang
Jingnan Pi
Dongling Zou
Xiaoshuang Wang
Jiayue Xu
Shan Yu
Ting Zhang
Feng Li
Xianxie Zhang
Hualu Zhao
Fang Wang
Dong Wang
Yanni Ma
Jia Yu
author_sort Zhengyi Zhang
title microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_short microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_full microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_fullStr microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_full_unstemmed microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
title_sort microrna arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description Functional miRNAs derived from the 5p or 3p arm of some miRNA duplexes have opposite roles in cancer progression. Here, the authors show that oncogenic miR-574-5p has greater preference in aggressive gastric cancer as compared with miR-574-3p and this arm preference is partly dependent on complementary targets mediated miRNA decay.
url https://doi.org/10.1038/s41467-019-12292-5
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