Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.
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Format: | Article |
Language: | English |
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Nature Publishing Group
2017-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms14175 |
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English |
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author |
Philip J. Law Sonja I. Berndt Helen E. Speedy Nicola J. Camp Georgina P. Sava Christine F. Skibola Amy Holroyd Vijai Joseph Nicola J. Sunter Alexandra Nieters Silvia Bea Alain Monnereau David Martin-Garcia Lynn R. Goldin Guillem Clot Lauren R. Teras Inés Quintela Brenda M. Birmann Sandrine Jayne Wendy Cozen Aneela Majid Karin E. Smedby Qing Lan Claire Dearden Angela R. Brooks-Wilson Andrew G. Hall Mark P. Purdue Tryfonia Mainou-Fowler Claire M. Vajdic Graham H. Jackson Pierluigi Cocco Helen Marr Yawei Zhang Tongzhang Zheng Graham G. Giles Charles Lawrence Timothy G. Call Mark Liebow Mads Melbye Bengt Glimelius Larry Mansouri Martha Glenn Karen Curtin W Ryan Diver Brian K. Link Lucia Conde Paige M. Bracci Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Paolo Boffetta Paul Brennan Marc Maynadie James McKay Demetrius Albanes Stephanie Weinstein Zhaoming Wang Neil E. Caporaso Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Roel C. H. Vermeulen Melissa C. Southey Roger L. Milne Jacqueline Clavel Sabine Topka John J. Spinelli Peter Kraft Maria Grazia Ennas Geoffrey Summerfield Giovanni M. Ferri Robert J. Harris Lucia Miligi Andrew R. Pettitt Kari E. North David J. Allsup Joseph F. Fraumeni James R. Bailey Kenneth Offit Guy Pratt Henrik Hjalgrim Chris Pepper Stephen J. Chanock Chris Fegan Richard Rosenquist Silvia de Sanjose Angel Carracedo Martin J. S. Dyer Daniel Catovsky Elias Campo James R. Cerhan James M. Allan Nathanial Rothman Richard Houlston Susan Slager |
spellingShingle |
Philip J. Law Sonja I. Berndt Helen E. Speedy Nicola J. Camp Georgina P. Sava Christine F. Skibola Amy Holroyd Vijai Joseph Nicola J. Sunter Alexandra Nieters Silvia Bea Alain Monnereau David Martin-Garcia Lynn R. Goldin Guillem Clot Lauren R. Teras Inés Quintela Brenda M. Birmann Sandrine Jayne Wendy Cozen Aneela Majid Karin E. Smedby Qing Lan Claire Dearden Angela R. Brooks-Wilson Andrew G. Hall Mark P. Purdue Tryfonia Mainou-Fowler Claire M. Vajdic Graham H. Jackson Pierluigi Cocco Helen Marr Yawei Zhang Tongzhang Zheng Graham G. Giles Charles Lawrence Timothy G. Call Mark Liebow Mads Melbye Bengt Glimelius Larry Mansouri Martha Glenn Karen Curtin W Ryan Diver Brian K. Link Lucia Conde Paige M. Bracci Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Paolo Boffetta Paul Brennan Marc Maynadie James McKay Demetrius Albanes Stephanie Weinstein Zhaoming Wang Neil E. Caporaso Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Roel C. H. Vermeulen Melissa C. Southey Roger L. Milne Jacqueline Clavel Sabine Topka John J. Spinelli Peter Kraft Maria Grazia Ennas Geoffrey Summerfield Giovanni M. Ferri Robert J. Harris Lucia Miligi Andrew R. Pettitt Kari E. North David J. Allsup Joseph F. Fraumeni James R. Bailey Kenneth Offit Guy Pratt Henrik Hjalgrim Chris Pepper Stephen J. Chanock Chris Fegan Richard Rosenquist Silvia de Sanjose Angel Carracedo Martin J. S. Dyer Daniel Catovsky Elias Campo James R. Cerhan James M. Allan Nathanial Rothman Richard Houlston Susan Slager Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia Nature Communications |
author_facet |
Philip J. Law Sonja I. Berndt Helen E. Speedy Nicola J. Camp Georgina P. Sava Christine F. Skibola Amy Holroyd Vijai Joseph Nicola J. Sunter Alexandra Nieters Silvia Bea Alain Monnereau David Martin-Garcia Lynn R. Goldin Guillem Clot Lauren R. Teras Inés Quintela Brenda M. Birmann Sandrine Jayne Wendy Cozen Aneela Majid Karin E. Smedby Qing Lan Claire Dearden Angela R. Brooks-Wilson Andrew G. Hall Mark P. Purdue Tryfonia Mainou-Fowler Claire M. Vajdic Graham H. Jackson Pierluigi Cocco Helen Marr Yawei Zhang Tongzhang Zheng Graham G. Giles Charles Lawrence Timothy G. Call Mark Liebow Mads Melbye Bengt Glimelius Larry Mansouri Martha Glenn Karen Curtin W Ryan Diver Brian K. Link Lucia Conde Paige M. Bracci Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Paolo Boffetta Paul Brennan Marc Maynadie James McKay Demetrius Albanes Stephanie Weinstein Zhaoming Wang Neil E. Caporaso Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Roel C. H. Vermeulen Melissa C. Southey Roger L. Milne Jacqueline Clavel Sabine Topka John J. Spinelli Peter Kraft Maria Grazia Ennas Geoffrey Summerfield Giovanni M. Ferri Robert J. Harris Lucia Miligi Andrew R. Pettitt Kari E. North David J. Allsup Joseph F. Fraumeni James R. Bailey Kenneth Offit Guy Pratt Henrik Hjalgrim Chris Pepper Stephen J. Chanock Chris Fegan Richard Rosenquist Silvia de Sanjose Angel Carracedo Martin J. S. Dyer Daniel Catovsky Elias Campo James R. Cerhan James M. Allan Nathanial Rothman Richard Houlston Susan Slager |
author_sort |
Philip J. Law |
title |
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
title_short |
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
title_full |
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
title_fullStr |
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
title_full_unstemmed |
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
title_sort |
genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-02-01 |
description |
Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function. |
url |
https://doi.org/10.1038/ncomms14175 |
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doaj-7260f008ee8e4abd981c7eed2433bb152021-05-11T07:53:12ZengNature Publishing GroupNature Communications2041-17232017-02-018111210.1038/ncomms14175Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemiaPhilip J. Law0Sonja I. Berndt1Helen E. Speedy2Nicola J. Camp3Georgina P. Sava4Christine F. Skibola5Amy Holroyd6Vijai Joseph7Nicola J. Sunter8Alexandra Nieters9Silvia Bea10Alain Monnereau11David Martin-Garcia12Lynn R. Goldin13Guillem Clot14Lauren R. Teras15Inés Quintela16Brenda M. Birmann17Sandrine Jayne18Wendy Cozen19Aneela Majid20Karin E. Smedby21Qing Lan22Claire Dearden23Angela R. Brooks-Wilson24Andrew G. Hall25Mark P. Purdue26Tryfonia Mainou-Fowler27Claire M. Vajdic28Graham H. Jackson29Pierluigi Cocco30Helen Marr31Yawei Zhang32Tongzhang Zheng33Graham G. Giles34Charles Lawrence35Timothy G. Call36Mark Liebow37Mads Melbye38Bengt Glimelius39Larry Mansouri40Martha Glenn41Karen Curtin42W Ryan Diver43Brian K. Link44Lucia Conde45Paige M. Bracci46Elizabeth A. Holly47Rebecca D. Jackson48Lesley F. Tinker49Yolanda Benavente50Paolo Boffetta51Paul Brennan52Marc Maynadie53James McKay54Demetrius Albanes55Stephanie Weinstein56Zhaoming Wang57Neil E. Caporaso58Lindsay M. Morton59Richard K. Severson60Elio Riboli61Paolo Vineis62Roel C. H. Vermeulen63Melissa C. Southey64Roger L. Milne65Jacqueline Clavel66Sabine Topka67John J. Spinelli68Peter Kraft69Maria Grazia Ennas70Geoffrey Summerfield71Giovanni M. Ferri72Robert J. Harris73Lucia Miligi74Andrew R. Pettitt75Kari E. North76David J. Allsup77Joseph F. Fraumeni78James R. Bailey79Kenneth Offit80Guy Pratt81Henrik Hjalgrim82Chris Pepper83Stephen J. Chanock84Chris Fegan85Richard Rosenquist86Silvia de Sanjose87Angel Carracedo88Martin J. S. Dyer89Daniel Catovsky90Elias Campo91James R. Cerhan92James M. Allan93Nathanial Rothman94Richard Houlston95Susan Slager96Division of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDepartment of Internal Medicine, Huntsman Cancer Institute, University of Utah School of MedicineDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at BirminghamDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDepartment of Medicine, Memorial Sloan Kettering Cancer CenterNorthern Institute for Cancer Research, Newcastle UniversityCenter for Chronic Immunodeficiency, University Medical Center FreiburgInstitut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital ClínicRegistre des hémopathies malignes de la Gironde, Institut Bergonié, Inserm U1219 EPICENEInstitut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital ClínicDivision of Cancer Epidemiology and Genetics, National Cancer InstituteInstitut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital ClínicEpidemiology Research Program, American Cancer SocietyGrupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERERChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolErnest and Helen Scott Haematological Research Institute, University of LeicesterDepartment of Preventive Medicine, USC Keck School of Medicine, University of Southern CaliforniaErnest and Helen Scott Haematological Research Institute, University of LeicesterDepartment of Medicine Solna, Unit of Clinical Epidemiology, Karolinska Institutet, Hematology Center, Karolinsak University HospitalDivision of Cancer Epidemiology and Genetics, National Cancer InstituteThe Royal Marsden NHS Foundation TrustGenome Sciences Centre, BC Cancer AgencyNorthern Institute for Cancer Research, Newcastle UniversityDivision of Cancer Epidemiology and Genetics, National Cancer InstituteHaematological Sciences, Medical School, Newcastle UniversityCentre for Big Data Research in Health, University of New South WalesDepartment of Haematology, Royal Victoria InfirmaryDepartment of Public Health, Clinical and Molecular Medicine, University of CagliariNorthern Institute for Cancer Research, Newcastle UniversityDepartment of Environmental Health Sciences, Yale School of Public HealthDepartment of Environmental Health Sciences, Yale School of Public HealthCancer Epidemiology Centre, Cancer Council VictoriaWestatDivision of Hematology, Mayo ClinicDepartment of Medicine, Mayo ClinicDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum InstitutDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala UniversityDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala UniversityDepartment of Internal Medicine, Huntsman Cancer Institute, University of Utah School of MedicineDepartment of Internal Medicine, Huntsman Cancer Institute, University of Utah School of MedicineEpidemiology Research Program, American Cancer SocietyDepartment of Internal Medicine, Carver College of Medicine, The University of IowaDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at BirminghamDepartment of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Epidemiology and Biostatistics, University of California San FranciscoDivision of Endocrinology, Diabetes and Metabolism, Ohio State UniversityDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de LlobregatThe Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiInternational Agency for Research on CancerRegistre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University HospitalInternational Agency for Research on CancerDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Computational Biology, St Jude Children’s Research HospitalDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Family Medicine and Public Health Sciences, Wayne State UniversitySchool of Public Health, Imperial College LondonMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College LondonInstitute for Risk Assessment Sciences, Utrecht UniversityDepartment of Pathology, Genetic Epidemiology Laboratory, University of MelbourneCancer Epidemiology Centre, Cancer Council VictoriaEpidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)Department of Medicine, Memorial Sloan Kettering Cancer CenterCancer Control Research, BC Cancer AgencyDepartment of Epidemiology, Harvard T.H. Chan School of Public HealthDepartment of Biomedical Science, University of CagliariDepartment of Haematology, Queen Elizabeth HospitalInterdisciplinary Department of Medicine, University of BariDepartment of Molecular and Clinical Cancer Medicine, University of LiverpoolEnvironmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO)Department of Molecular and Clinical Cancer Medicine, University of LiverpoolDepartment of Epidemiology, University of North Carolina at Chapel HillQueens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS TrustDivision of Cancer Epidemiology and Genetics, National Cancer InstituteQueens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS TrustDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Haematology, Birmingham Heartlands HospitalDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum InstitutDivision of Cancer and Genetics, School of Medicine, Cardiff UniversityDivision of Cancer Epidemiology and Genetics, National Cancer InstituteCardiff and Vale National Health Service Trust, Heath ParkDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala UniversityThe Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiGrupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERERErnest and Helen Scott Haematological Research Institute, University of LeicesterDivision of Molecular Pathology, The Institute of Cancer ResearchInstitut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital ClínicDepartment of Health Sciences Research, Mayo ClinicNorthern Institute for Cancer Research, Newcastle UniversityDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDepartment of Health Sciences Research, Mayo ClinicChronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.https://doi.org/10.1038/ncomms14175 |