Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers.
Since 2013, rabies cases have been reported among Formosan ferret badgers in Taiwan, and they have been shown to be the major reservoirs for Taiwanese enzootics. To control and eradicate rabies, the authorities plan to implement a vaccination programme. Before distributing live vaccines in the field...
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2017-01-01
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doaj-7262e3a52fd14d5c80f608e64d9115b32020-11-25T00:24:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011210e018483110.1371/journal.pone.0184831Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers.Ai-Ping HsuChun-Hsien TsengJacques BarratShu-Hwae LeeYu-Hua ShihMarine WasniewskiPhilippe MählChia-Chia ChangChun-Ta LinRe-Shang ChenWen-Jane TuFlorence CliquetHsiang-Jung TsaiSince 2013, rabies cases have been reported among Formosan ferret badgers in Taiwan, and they have been shown to be the major reservoirs for Taiwanese enzootics. To control and eradicate rabies, the authorities plan to implement a vaccination programme. Before distributing live vaccines in the field, this study assessed the safety, efficacy, and immunogenicity of SAG2 vaccine on ferret badgers by direct oral instillation. After application of 109 TCID50/dose, no virus was excreted into the oral cavity 1-7 days post-application, and safety was also satisfactorily verified over a 266-day period. Moreover, despite the low level of rabies virus neutralising antibodies induced after vaccination of a 108 TCID50/dose, the efficacy assessment revealed a 100% survival rate (15/15) of vaccinees and an 87.5% fatality rate (7/8) in control animals after a challenge on the 198th day post-vaccination. The immunisation and protection rates obtained more than 6 months after a single vaccination dose demonstrated that SAG2 is an ideal vaccine candidate to protect Formosan ferret badgers against rabies in Taiwan.http://europepmc.org/articles/PMC5627901?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ai-Ping Hsu Chun-Hsien Tseng Jacques Barrat Shu-Hwae Lee Yu-Hua Shih Marine Wasniewski Philippe Mähl Chia-Chia Chang Chun-Ta Lin Re-Shang Chen Wen-Jane Tu Florence Cliquet Hsiang-Jung Tsai |
spellingShingle |
Ai-Ping Hsu Chun-Hsien Tseng Jacques Barrat Shu-Hwae Lee Yu-Hua Shih Marine Wasniewski Philippe Mähl Chia-Chia Chang Chun-Ta Lin Re-Shang Chen Wen-Jane Tu Florence Cliquet Hsiang-Jung Tsai Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers. PLoS ONE |
author_facet |
Ai-Ping Hsu Chun-Hsien Tseng Jacques Barrat Shu-Hwae Lee Yu-Hua Shih Marine Wasniewski Philippe Mähl Chia-Chia Chang Chun-Ta Lin Re-Shang Chen Wen-Jane Tu Florence Cliquet Hsiang-Jung Tsai |
author_sort |
Ai-Ping Hsu |
title |
Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers. |
title_short |
Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers. |
title_full |
Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers. |
title_fullStr |
Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers. |
title_full_unstemmed |
Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers. |
title_sort |
safety, efficacy and immunogenicity evaluation of the sag2 oral rabies vaccine in formosan ferret badgers. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Since 2013, rabies cases have been reported among Formosan ferret badgers in Taiwan, and they have been shown to be the major reservoirs for Taiwanese enzootics. To control and eradicate rabies, the authorities plan to implement a vaccination programme. Before distributing live vaccines in the field, this study assessed the safety, efficacy, and immunogenicity of SAG2 vaccine on ferret badgers by direct oral instillation. After application of 109 TCID50/dose, no virus was excreted into the oral cavity 1-7 days post-application, and safety was also satisfactorily verified over a 266-day period. Moreover, despite the low level of rabies virus neutralising antibodies induced after vaccination of a 108 TCID50/dose, the efficacy assessment revealed a 100% survival rate (15/15) of vaccinees and an 87.5% fatality rate (7/8) in control animals after a challenge on the 198th day post-vaccination. The immunisation and protection rates obtained more than 6 months after a single vaccination dose demonstrated that SAG2 is an ideal vaccine candidate to protect Formosan ferret badgers against rabies in Taiwan. |
url |
http://europepmc.org/articles/PMC5627901?pdf=render |
work_keys_str_mv |
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