Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a negative regulator of PI3K signaling, under varyin...

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Bibliographic Details
Main Authors: Katarzyna Nowak, Gerhard Seisenbacher, Ernst Hafen, Hugo Stocker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-07-01
Series:eLife
Subjects:
tumor suppression
PTEN
insulin signaling
hyperplasia
apoptosis
nutrient restriction
Online Access:https://elifesciences.org/articles/00380

Internet

https://elifesciences.org/articles/00380

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