Human Bone Marrow Mesenchymal Stromal Cell-Derived CXCL12, IL-6 and GDF-15 and Their Capacity to Support IgG-Secreting Cells in Culture Are Divergently Affected by Doxorubicin

Human Bone Marrow Mesenchymal Stromal Cell-Derived CXCL12, IL-6 and GDF-15 and Their Capacity to Support IgG-Secreting Cells in Culture Are Divergently Affected by Doxorubicin

Various subsets of bone marrow mesenchymal stromal cells (BM MSCs), including fibroblasts, endothelial, fat and reticular cells, are implicated in the regulation of the hematopoietic microenvironment and the survival of long-lived antibody-secreting cells (ASCs). Nowadays it is widely acknowledged t...

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Bibliographic Details
Main Authors: Gintare Lasaviciute, Anna Höbinger, Dorina Ujvari, Daniel Salamon, Aisha Yusuf, Mikael Sundin, Eva Sverremark-Ekström, Rayan Chikhi, Anna Nilsson, Shanie Saghafian-Hedengren
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Hemato
Subjects:
human bone marrow mesenchymal stromal cells
anthracycline
plasma cell niche
cytokines
chemokines
antibody-secreting cells
Online Access:https://www.mdpi.com/2673-6357/2/1/9

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https://www.mdpi.com/2673-6357/2/1/9

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