Ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and MMPs
Objective: To study the correlation of the ultrasound parameters of left ventricular remodeling and systolic synchrony in patients with primary hypertension with serum cytokines and matrix metalloproteinases (MMPs). Methods: 134 patients with primary hypertension receiving three-dimensional echoc...
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doaj-727b2bd2777e4c1c9127d0a6287960952020-11-25T00:58:52ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12372017-01-012312427Ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and MMPsHai-Yan Kou0Li Liang1Jin-Hua Su2Department of Ultrasonography, General Hospital of Chinese People’s Armed Police Forces, Beijing, 100039, ChinaDepartment of Ultrasonography, General Hospital of Chinese People’s Armed Police Forces, Beijing, 100039, ChinaDepartment of Ultrasonography, General Hospital of Chinese People’s Armed Police Forces, Beijing, 100039, ChinaObjective: To study the correlation of the ultrasound parameters of left ventricular remodeling and systolic synchrony in patients with primary hypertension with serum cytokines and matrix metalloproteinases (MMPs). Methods: 134 patients with primary hypertension receiving three-dimensional echocardiography examination in our hospital between May 2013 and March 2016 were selected and divided into the group A with normal pattern (n=71), group B with concentric hypertrophy (n=39) and group C with eccentric hypertrophy (n=24) according to the left ventricular internal diameter at end-diastole (LVIDd) and left ventricular mass index (LVMI), and the ultrasound parameters of left ventricular remodeling and systolic synchrony as well as serum content of cytokines and MMPs were determined. Results: The time to minimal systolic volume of 16-segmental standard deviation (SDI), maximum time difference (DIF), Tpe, Tpe interphase and its correction (Tpec), LVIDd, LVMI and left ventricular remodeling index (LVRI) of group B and group C were significantly higher than those of group A (P<0.05), and SDI, DIF, Tpe, Tpec, LVIDd, LVMI and LVRI of group C were significantly higher than those of group B (P<0.05); serum tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17), transforming growth factor-β1 (TGF-β1), matrix metalloproteinase 2 (MMP2), MMP3 and MMP9 content of group B and group C were significantly higher than those of group A (P<0.05), and serum TNF-α, IL-17, TGF-β1, MMP2, MMP3 and MMP9 content of group C were significantly higher than those of group B (P<0.05) and positively correlated with LVIDd, LVMI, LVRI, SDI, DIF, Tpe and Tpec; serum TIMP1 and TIMP2 content of group B and group C were significantly lower than those of group A (P<0.05), and serum TIMP1 and TIMP2 content of group C were significantly lower than those of group B (P<0.05) and negatively correlated with LVIDd, LVMI, LVRI, SDI, DIF, Tpe and Tpec. Conclusions: The ultrasound parameters of left ventricular remodeling and systolic synchrony significantly change in patients with primary hypertension and are closely related to the changes in the content of serum cytokines and MMPs.http://www.hnykdxxb.com/PDF/201701/7.pdfPrimary hypertensionLeft ventricular remodelingSystolic synchronycytokineMatrix metalloproteinase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hai-Yan Kou Li Liang Jin-Hua Su |
spellingShingle |
Hai-Yan Kou Li Liang Jin-Hua Su Ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and MMPs Journal of Hainan Medical University Primary hypertension Left ventricular remodeling Systolic synchrony cytokine Matrix metalloproteinase |
author_facet |
Hai-Yan Kou Li Liang Jin-Hua Su |
author_sort |
Hai-Yan Kou |
title |
Ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and MMPs |
title_short |
Ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and MMPs |
title_full |
Ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and MMPs |
title_fullStr |
Ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and MMPs |
title_full_unstemmed |
Ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and MMPs |
title_sort |
ultrasound evaluation of left ventricular remodeling and systolic synchrony in patients with primary hypertension and the correlation with serum cytokines and mmps |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 |
publishDate |
2017-01-01 |
description |
Objective: To study the correlation of the ultrasound parameters of left ventricular remodeling
and systolic synchrony in patients with primary hypertension with serum cytokines and matrix
metalloproteinases (MMPs). Methods: 134 patients with primary hypertension receiving
three-dimensional echocardiography examination in our hospital between May 2013 and
March 2016 were selected and divided into the group A with normal pattern (n=71), group B
with concentric hypertrophy (n=39) and group C with eccentric hypertrophy (n=24) according
to the left ventricular internal diameter at end-diastole (LVIDd) and left ventricular mass index
(LVMI), and the ultrasound parameters of left ventricular remodeling and systolic synchrony as
well as serum content of cytokines and MMPs were determined. Results: The time to minimal
systolic volume of 16-segmental standard deviation (SDI), maximum time difference (DIF),
Tpe, Tpe interphase and its correction (Tpec), LVIDd, LVMI and left ventricular remodeling
index (LVRI) of group B and group C were significantly higher than those of group A (P<0.05),
and SDI, DIF, Tpe, Tpec, LVIDd, LVMI and LVRI of group C were significantly higher than
those of group B (P<0.05); serum tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17),
transforming growth factor-β1 (TGF-β1), matrix metalloproteinase 2 (MMP2), MMP3 and
MMP9 content of group B and group C were significantly higher than those of group A
(P<0.05), and serum TNF-α, IL-17, TGF-β1, MMP2, MMP3 and MMP9 content of group
C were significantly higher than those of group B (P<0.05) and positively correlated with
LVIDd, LVMI, LVRI, SDI, DIF, Tpe and Tpec; serum TIMP1 and TIMP2 content of group
B and group C were significantly lower than those of group A (P<0.05), and serum TIMP1
and TIMP2 content of group C were significantly lower than those of group B (P<0.05) and
negatively correlated with LVIDd, LVMI, LVRI, SDI, DIF, Tpe and Tpec. Conclusions: The
ultrasound parameters of left ventricular remodeling and systolic synchrony significantly
change in patients with primary hypertension and are closely related to the changes in the
content of serum cytokines and MMPs. |
topic |
Primary hypertension Left ventricular remodeling Systolic synchrony cytokine Matrix metalloproteinase |
url |
http://www.hnykdxxb.com/PDF/201701/7.pdf |
work_keys_str_mv |
AT haiyankou ultrasoundevaluationofleftventricularremodelingandsystolicsynchronyinpatientswithprimaryhypertensionandthecorrelationwithserumcytokinesandmmps AT liliang ultrasoundevaluationofleftventricularremodelingandsystolicsynchronyinpatientswithprimaryhypertensionandthecorrelationwithserumcytokinesandmmps AT jinhuasu ultrasoundevaluationofleftventricularremodelingandsystolicsynchronyinpatientswithprimaryhypertensionandthecorrelationwithserumcytokinesandmmps |
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