Genetic susceptibility to HPV infection and cervical cancer
Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of...
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Associação Brasileira de Divulgação Científica
1999-07-01
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doaj-727d5a347927421b9fbd7755357491f52020-11-24T21:52:08ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1999-07-0132791592210.1590/S0100-879X1999000700017Genetic susceptibility to HPV infection and cervical cancerP.C. MaciagL.L. VillaSquamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700017human papillomaviruscervical cancerHLAp53polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
P.C. Maciag L.L. Villa |
spellingShingle |
P.C. Maciag L.L. Villa Genetic susceptibility to HPV infection and cervical cancer Brazilian Journal of Medical and Biological Research human papillomavirus cervical cancer HLA p53 polymorphism |
author_facet |
P.C. Maciag L.L. Villa |
author_sort |
P.C. Maciag |
title |
Genetic susceptibility to HPV infection and cervical cancer |
title_short |
Genetic susceptibility to HPV infection and cervical cancer |
title_full |
Genetic susceptibility to HPV infection and cervical cancer |
title_fullStr |
Genetic susceptibility to HPV infection and cervical cancer |
title_full_unstemmed |
Genetic susceptibility to HPV infection and cervical cancer |
title_sort |
genetic susceptibility to hpv infection and cervical cancer |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 1414-431X |
publishDate |
1999-07-01 |
description |
Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation. |
topic |
human papillomavirus cervical cancer HLA p53 polymorphism |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700017 |
work_keys_str_mv |
AT pcmaciag geneticsusceptibilitytohpvinfectionandcervicalcancer AT llvilla geneticsusceptibilitytohpvinfectionandcervicalcancer |
_version_ |
1725876669596565504 |