Laboratory Animal Models for Brucellosis Research
Brucellosis is a chronic infectious disease caused by Brucella spp., a Gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the wo...
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doaj-727f2d2325eb45dbb7ed2c33ed4d5b532020-11-24T21:28:51ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512011-01-01201110.1155/2011/518323518323Laboratory Animal Models for Brucellosis ResearchTeane M. A. Silva0Erica A. Costa1Tatiane A. Paixão2Renée M. Tsolis3Renato L. Santos4Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinária (EV), Universidade Federal de Minas Gerais (UFMG), 31270-901 Belo Horizonte, MG, BrazilDepartamento de Clínica e Cirurgia Veterinária, Escola de Veterinária (EV), Universidade Federal de Minas Gerais (UFMG), 31270-901 Belo Horizonte, MG, BrazilDepartamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilDepartment of Medical Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USADepartamento de Clínica e Cirurgia Veterinária, Escola de Veterinária (EV), Universidade Federal de Minas Gerais (UFMG), 31270-901 Belo Horizonte, MG, BrazilBrucellosis is a chronic infectious disease caused by Brucella spp., a Gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects of Brucella pathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused by Brucella. This model is most frequently used to investigate specific pathogenic factors of Brucella spp., to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis.http://dx.doi.org/10.1155/2011/518323 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Teane M. A. Silva Erica A. Costa Tatiane A. Paixão Renée M. Tsolis Renato L. Santos |
spellingShingle |
Teane M. A. Silva Erica A. Costa Tatiane A. Paixão Renée M. Tsolis Renato L. Santos Laboratory Animal Models for Brucellosis Research Journal of Biomedicine and Biotechnology |
author_facet |
Teane M. A. Silva Erica A. Costa Tatiane A. Paixão Renée M. Tsolis Renato L. Santos |
author_sort |
Teane M. A. Silva |
title |
Laboratory Animal Models for Brucellosis Research |
title_short |
Laboratory Animal Models for Brucellosis Research |
title_full |
Laboratory Animal Models for Brucellosis Research |
title_fullStr |
Laboratory Animal Models for Brucellosis Research |
title_full_unstemmed |
Laboratory Animal Models for Brucellosis Research |
title_sort |
laboratory animal models for brucellosis research |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2011-01-01 |
description |
Brucellosis is a chronic infectious disease caused by Brucella spp., a Gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects of Brucella pathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused by Brucella. This model is most frequently used to investigate specific pathogenic factors of Brucella spp., to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis. |
url |
http://dx.doi.org/10.1155/2011/518323 |
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