Animal and Organoid Models of Liver Fibrosis
Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the...
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doaj-728435f286a64e54a23b8f90943c52342021-05-26T06:46:09ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-05-011210.3389/fphys.2021.666138666138Animal and Organoid Models of Liver FibrosisYu-long Bao0Li Wang1Hai-ting Pan2Tai-ran Zhang3Ya-hong Chen4Shan-jing Xu5Xin-li Mao6Xin-li Mao7Xin-li Mao8Shao-wei Li9Shao-wei Li10College of Basic Medicine, Inner Mongolia Medical University, Hohhot, ChinaCollege of Basic Medicine, Inner Mongolia Medical University, Hohhot, ChinaCollege of Basic Medicine, Inner Mongolia Medical University, Hohhot, ChinaCollege of Basic Medicine, Inner Mongolia Medical University, Hohhot, ChinaHealth Management Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaSchool of Medicine, Shaoxing University, Shaoxing, ChianSchool of Medicine, Shaoxing University, Shaoxing, ChianKey Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaDepartment of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaKey Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaDepartment of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaLiver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver. Liver fibrosis thus constitutes the pathological repair response of the liver to chronic injury. Hepatic fibrosis is a key step in the progression of chronic liver disease to cirrhosis and an important factor affecting the prognosis of chronic liver disease. Further development of liver fibrosis may lead to structural disorders of the liver, nodular regeneration of hepatocytes and the formation of cirrhosis. Hepatic fibrosis is histologically reversible if treated aggressively during this period, but when fibrosis progresses to the stage of cirrhosis, reversal is very difficult, resulting in a poor prognosis. There are many causes of liver fibrosis, including liver injury caused by drugs, viral hepatitis, alcoholic liver, fatty liver and autoimmune disease. The mechanism underlying hepatic fibrosis differs among etiologies. The establishment of an appropriate animal model of liver fibrosis is not only an important basis for the in-depth study of the pathogenesis of liver fibrosis but also an important means for clinical experts to select drugs for the prevention and treatment of liver fibrosis. The present study focused on the modeling methods and fibrosis characteristics of different animal models of liver fibrosis, such as a chemical-induced liver fibrosis model, autoimmune liver fibrosis model, cholestatic liver fibrosis model, alcoholic liver fibrosis model and non-alcoholic liver fibrosis model. In addition, we also summarize the research and application prospects concerning new organoids in liver fibrosis models proposed in recent years. A suitable animal model of liver fibrosis and organoid fibrosis model that closely resemble the physiological state of the human body will provide bases for the in-depth study of the pathogenesis of liver fibrosis and the development of therapeutic drugs.https://www.frontiersin.org/articles/10.3389/fphys.2021.666138/fullliverfibrosisanimalorganoidmodel |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-long Bao Li Wang Hai-ting Pan Tai-ran Zhang Ya-hong Chen Shan-jing Xu Xin-li Mao Xin-li Mao Xin-li Mao Shao-wei Li Shao-wei Li |
spellingShingle |
Yu-long Bao Li Wang Hai-ting Pan Tai-ran Zhang Ya-hong Chen Shan-jing Xu Xin-li Mao Xin-li Mao Xin-li Mao Shao-wei Li Shao-wei Li Animal and Organoid Models of Liver Fibrosis Frontiers in Physiology liver fibrosis animal organoid model |
author_facet |
Yu-long Bao Li Wang Hai-ting Pan Tai-ran Zhang Ya-hong Chen Shan-jing Xu Xin-li Mao Xin-li Mao Xin-li Mao Shao-wei Li Shao-wei Li |
author_sort |
Yu-long Bao |
title |
Animal and Organoid Models of Liver Fibrosis |
title_short |
Animal and Organoid Models of Liver Fibrosis |
title_full |
Animal and Organoid Models of Liver Fibrosis |
title_fullStr |
Animal and Organoid Models of Liver Fibrosis |
title_full_unstemmed |
Animal and Organoid Models of Liver Fibrosis |
title_sort |
animal and organoid models of liver fibrosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-05-01 |
description |
Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver. Liver fibrosis thus constitutes the pathological repair response of the liver to chronic injury. Hepatic fibrosis is a key step in the progression of chronic liver disease to cirrhosis and an important factor affecting the prognosis of chronic liver disease. Further development of liver fibrosis may lead to structural disorders of the liver, nodular regeneration of hepatocytes and the formation of cirrhosis. Hepatic fibrosis is histologically reversible if treated aggressively during this period, but when fibrosis progresses to the stage of cirrhosis, reversal is very difficult, resulting in a poor prognosis. There are many causes of liver fibrosis, including liver injury caused by drugs, viral hepatitis, alcoholic liver, fatty liver and autoimmune disease. The mechanism underlying hepatic fibrosis differs among etiologies. The establishment of an appropriate animal model of liver fibrosis is not only an important basis for the in-depth study of the pathogenesis of liver fibrosis but also an important means for clinical experts to select drugs for the prevention and treatment of liver fibrosis. The present study focused on the modeling methods and fibrosis characteristics of different animal models of liver fibrosis, such as a chemical-induced liver fibrosis model, autoimmune liver fibrosis model, cholestatic liver fibrosis model, alcoholic liver fibrosis model and non-alcoholic liver fibrosis model. In addition, we also summarize the research and application prospects concerning new organoids in liver fibrosis models proposed in recent years. A suitable animal model of liver fibrosis and organoid fibrosis model that closely resemble the physiological state of the human body will provide bases for the in-depth study of the pathogenesis of liver fibrosis and the development of therapeutic drugs. |
topic |
liver fibrosis animal organoid model |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2021.666138/full |
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