cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

Abstract Background The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα, part of the GPIb-IX-V complex, has several physiological ligands such as von Willebrand factor (vWF), thrombospondin and di...

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Bibliographic Details
Main Authors: Stephanie Makhoul, Katharina Trabold, Stepan Gambaryan, Stefan Tenzer, Daniele Pillitteri, Ulrich Walter, Kerstin Jurk
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Cell Communication and Signaling
Subjects:
cAMP-dependent protein kinase
cGMP-dependent protein kinase
Glycoprotein receptor GPIb-IX
Platelet activation
Syk kinase
Online Access:http://link.springer.com/article/10.1186/s12964-019-0428-1

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http://link.springer.com/article/10.1186/s12964-019-0428-1

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