Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival.
The Gram-negative bacterium, Legionella pneumophila, is a protozoan parasite and accidental intracellular pathogen of humans. We propose a model in which cycling through multiple protozoan hosts in the environment holds L. pneumophila in a state of evolutionary stasis as a broad host-range pathogen....
Main Authors: | Alexander W Ensminger, Yosuf Yassin, Alexander Miron, Ralph R Isberg |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3364954?pdf=render |
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