Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature
A 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific...
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doaj-72a8340d77db4a2cb9218032573e1bd32020-11-25T00:53:56ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-01265962Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literatureShuko Hirota0Yoichi Kobayashi1Takashi Ishiguro2Takashi Nishida3Naho Kagiyama4Yoshihiko Shimizu5Noboru Takayanagi6Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan; Corresponding author.Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, JapanDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, JapanDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, JapanDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, JapanDepartment of Pathology, Saitama Cardiovascular and Respiratory Center, JapanDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, JapanA 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against Aspergillus sp., central bronchiectasis, and mucoid impaction. Systemic corticosteroids and anti-fungal therapy improved her symptoms, but the cessation of these treatments led to frequent exacerbations. Omalizumab improved her asthmatic symptoms to the point that corticosteroids could be stopped; however, radiological findings were not improved, and coexisting eosinophilic sinusitis and otitis media worsened. After her treatment was changed from omalizumab to mepolizumab, not only her asthmatic symptoms but also her sinusitis and otitis media became well controlled, and chest radiological findings improved. Keywords: Allergic bronchopulmonary aspergillosis, Omalizumab, Mepolizumab, Corticosteroid, Itraconazolehttp://www.sciencedirect.com/science/article/pii/S2213007118303368 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuko Hirota Yoichi Kobayashi Takashi Ishiguro Takashi Nishida Naho Kagiyama Yoshihiko Shimizu Noboru Takayanagi |
spellingShingle |
Shuko Hirota Yoichi Kobayashi Takashi Ishiguro Takashi Nishida Naho Kagiyama Yoshihiko Shimizu Noboru Takayanagi Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature Respiratory Medicine Case Reports |
author_facet |
Shuko Hirota Yoichi Kobayashi Takashi Ishiguro Takashi Nishida Naho Kagiyama Yoshihiko Shimizu Noboru Takayanagi |
author_sort |
Shuko Hirota |
title |
Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature |
title_short |
Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature |
title_full |
Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature |
title_fullStr |
Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature |
title_full_unstemmed |
Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature |
title_sort |
allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: case report and review of the literature |
publisher |
Elsevier |
series |
Respiratory Medicine Case Reports |
issn |
2213-0071 |
publishDate |
2019-01-01 |
description |
A 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against Aspergillus sp., central bronchiectasis, and mucoid impaction. Systemic corticosteroids and anti-fungal therapy improved her symptoms, but the cessation of these treatments led to frequent exacerbations. Omalizumab improved her asthmatic symptoms to the point that corticosteroids could be stopped; however, radiological findings were not improved, and coexisting eosinophilic sinusitis and otitis media worsened. After her treatment was changed from omalizumab to mepolizumab, not only her asthmatic symptoms but also her sinusitis and otitis media became well controlled, and chest radiological findings improved. Keywords: Allergic bronchopulmonary aspergillosis, Omalizumab, Mepolizumab, Corticosteroid, Itraconazole |
url |
http://www.sciencedirect.com/science/article/pii/S2213007118303368 |
work_keys_str_mv |
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