Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis
How effective and safe are incobotulinumtoxinA injections in adult patients with lateral epicondylitis refractory to other treatments? In this experimental study, ultrasound-guided incobotulinumtoxinA 10–30 U/muscle was injected into extensor carpi ulnaris, extensor digiti minimi, extensor...
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doaj-72ad0e918fe84045ab536665788a9ee62020-11-24T20:43:52ZengMDPI AGToxins2072-66512019-01-011114610.3390/toxins11010046toxins11010046Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral EpicondylitisAntonio Galván Ruiz0Gloria Vergara Díaz1Beatriz Rendón Fernández2Carmen Echevarría Ruiz De Vargas3Physical Medicine and Rehabilitation, Hospital Universitario Virgen del Rocío, 41013 Seville, SpainPhysical Medicine and Rehabilitation, Hospital Universitario Virgen del Rocío, 41013 Seville, SpainPhysical Medicine and Rehabilitation, Hospital Universitario Virgen del Rocío, 41013 Seville, SpainPhysical Medicine and Rehabilitation, Hospital Universitario Virgen del Rocío, 41013 Seville, SpainHow effective and safe are incobotulinumtoxinA injections in adult patients with lateral epicondylitis refractory to other treatments? In this experimental study, ultrasound-guided incobotulinumtoxinA 10–30 U/muscle was injected into extensor carpi ulnaris, extensor digiti minimi, extensor digitorum longus and extensor carpi radialis brevis muscles. Pain (visual analogue scale [VAS], 0 to 10 [no pain to severe pain]) and upper-limb functionality (QuickDASH scale, 0 to 100 [best to worst]), assessed at baseline, 1, 3 and 6 months post-treatment, were analysed using repeated-measures analysis of variance (ANOVA) and Tukey post-hoc tests. Secondary analyses stratifying patient population by sex and baseline VAS were performed. Adverse events were reported. Twenty-four patients (mean [standard deviation] age 46.8 years) were included. Compared with baseline, mean VAS and QuickDASH scores improved at all follow-ups (p < 0.001 and p = 0.001, respectively; repeated-measures ANOVA). Secondary analyses revealed significant differences between baseline and all follow-ups in the group with baseline VAS ≥ 6 and in males and females (all p < 0.05, Tukey post-hoc test). No adverse events, except for the expected third finger weakness, were reported. In conclusion, ultrasound-guided incobotulinumtoxinA injections may be an effective treatment for lateral epicondylitis in the appropriate patient population.http://www.mdpi.com/2072-6651/11/1/46lateral epicondylitistennis elbowbotulinum toxin AincobotulinumtoxinApainrehabilitation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonio Galván Ruiz Gloria Vergara Díaz Beatriz Rendón Fernández Carmen Echevarría Ruiz De Vargas |
spellingShingle |
Antonio Galván Ruiz Gloria Vergara Díaz Beatriz Rendón Fernández Carmen Echevarría Ruiz De Vargas Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis Toxins lateral epicondylitis tennis elbow botulinum toxin A incobotulinumtoxinA pain rehabilitation |
author_facet |
Antonio Galván Ruiz Gloria Vergara Díaz Beatriz Rendón Fernández Carmen Echevarría Ruiz De Vargas |
author_sort |
Antonio Galván Ruiz |
title |
Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis |
title_short |
Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis |
title_full |
Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis |
title_fullStr |
Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis |
title_full_unstemmed |
Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis |
title_sort |
effects of ultrasound-guided administration of botulinum toxin (incobotulinumtoxina) in patients with lateral epicondylitis |
publisher |
MDPI AG |
series |
Toxins |
issn |
2072-6651 |
publishDate |
2019-01-01 |
description |
How effective and safe are incobotulinumtoxinA injections in adult patients with lateral epicondylitis refractory to other treatments? In this experimental study, ultrasound-guided incobotulinumtoxinA 10–30 U/muscle was injected into extensor carpi ulnaris, extensor digiti minimi, extensor digitorum longus and extensor carpi radialis brevis muscles. Pain (visual analogue scale [VAS], 0 to 10 [no pain to severe pain]) and upper-limb functionality (QuickDASH scale, 0 to 100 [best to worst]), assessed at baseline, 1, 3 and 6 months post-treatment, were analysed using repeated-measures analysis of variance (ANOVA) and Tukey post-hoc tests. Secondary analyses stratifying patient population by sex and baseline VAS were performed. Adverse events were reported. Twenty-four patients (mean [standard deviation] age 46.8 years) were included. Compared with baseline, mean VAS and QuickDASH scores improved at all follow-ups (p < 0.001 and p = 0.001, respectively; repeated-measures ANOVA). Secondary analyses revealed significant differences between baseline and all follow-ups in the group with baseline VAS ≥ 6 and in males and females (all p < 0.05, Tukey post-hoc test). No adverse events, except for the expected third finger weakness, were reported. In conclusion, ultrasound-guided incobotulinumtoxinA injections may be an effective treatment for lateral epicondylitis in the appropriate patient population. |
topic |
lateral epicondylitis tennis elbow botulinum toxin A incobotulinumtoxinA pain rehabilitation |
url |
http://www.mdpi.com/2072-6651/11/1/46 |
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